Protein assembly by design
Proteins are nature's primary building blocks for the construction of sophisticated molecular
machines and dynamic materials, ranging from protein complexes such as photosystem II …
machines and dynamic materials, ranging from protein complexes such as photosystem II …
De novo protein design, a retrospective
IV Korendovych, WF DeGrado - Quarterly reviews of biophysics, 2020 - cambridge.org
Proteins are molecular machines whose function depends on their ability to achieve
complex folds with precisely defined structural and dynamic properties. The rational design …
complex folds with precisely defined structural and dynamic properties. The rational design …
[HTML][HTML] Illuminating protein space with a programmable generative model
Three billion years of evolution has produced a tremendous diversity of protein molecules,
but the full potential of proteins is likely to be much greater. Accessing this potential has …
but the full potential of proteins is likely to be much greater. Accessing this potential has …
[HTML][HTML] De novo design of a nanopore for single-molecule detection that incorporates a β-hairpin peptide
K Shimizu, B Mijiddorj, M Usami, I Mizoguchi… - Nature …, 2022 - nature.com
The amino-acid sequence of a protein encodes information on its three-dimensional
structure and specific functionality. De novo design has emerged as a method to manipulate …
structure and specific functionality. De novo design has emerged as a method to manipulate …
[HTML][HTML] Liposomes as adjuvants and vaccine delivery systems
DS Tretiakova, EL Vodovozova - … Series A: Membrane and Cell Biology, 2022 - Springer
The review considers liposomes as systems of substantial interest as adjuvant carriers in
vaccinology due to their versatility and maximal biocompatibility. Research and …
vaccinology due to their versatility and maximal biocompatibility. Research and …
Fluorescent amino acids as versatile building blocks for chemical biology
Fluorophores have transformed the way we study biological systems, enabling non-invasive
studies in cells and intact organisms, which increase our understanding of complex …
studies in cells and intact organisms, which increase our understanding of complex …
Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns
WS Horne, TN Grossmann - Nature chemistry, 2020 - nature.com
Proteins have evolved as a variable platform that provides access to molecules with diverse
shapes, sizes and functions. These features have inspired chemists for decades to seek …
shapes, sizes and functions. These features have inspired chemists for decades to seek …
Integrating Computation, Experiment, and Machine Learning in the Design of Peptide‐Based Supramolecular Materials and Systems
M Ramakrishnan, A van Teijlingen… - Angewandte Chemie …, 2023 - Wiley Online Library
Interest in peptide‐based supramolecular materials has grown extensively since the 1980s
and the application of computational methods has paralleled this. These methods contribute …
and the application of computational methods has paralleled this. These methods contribute …
Precise assembly of proteins and carbohydrates for next-generation biomaterials
L Li, G Chen - Journal of the American Chemical Society, 2022 - ACS Publications
The complexity and diversity of biomacromolecules make them a unique class of building
blocks for generating precise assemblies. They are particularly available to a new …
blocks for generating precise assemblies. They are particularly available to a new …
Hollow octadecameric self-assembly of collagen-like peptides
LT Yu, MC Hancu, MAB Kreutzberger… - Journal of the …, 2023 - ACS Publications
The folding of collagen is a hierarchical process that starts with three peptides associating
into the characteristic triple helical fold. Depending on the specific collagen in question …
into the characteristic triple helical fold. Depending on the specific collagen in question …