Protein assembly by design

J Zhu, N Avakyan, A Kakkis, AM Hoffnagle… - Chemical …, 2021 - ACS Publications
Proteins are nature's primary building blocks for the construction of sophisticated molecular
machines and dynamic materials, ranging from protein complexes such as photosystem II …

De novo protein design, a retrospective

IV Korendovych, WF DeGrado - Quarterly reviews of biophysics, 2020 - cambridge.org
Proteins are molecular machines whose function depends on their ability to achieve
complex folds with precisely defined structural and dynamic properties. The rational design …

[HTML][HTML] Illuminating protein space with a programmable generative model

JB Ingraham, M Baranov, Z Costello, KW Barber… - Nature, 2023 - nature.com
Three billion years of evolution has produced a tremendous diversity of protein molecules,
but the full potential of proteins is likely to be much greater. Accessing this potential has …

[HTML][HTML] De novo design of a nanopore for single-molecule detection that incorporates a β-hairpin peptide

K Shimizu, B Mijiddorj, M Usami, I Mizoguchi… - Nature …, 2022 - nature.com
The amino-acid sequence of a protein encodes information on its three-dimensional
structure and specific functionality. De novo design has emerged as a method to manipulate …

[HTML][HTML] Liposomes as adjuvants and vaccine delivery systems

DS Tretiakova, EL Vodovozova - … Series A: Membrane and Cell Biology, 2022 - Springer
The review considers liposomes as systems of substantial interest as adjuvant carriers in
vaccinology due to their versatility and maximal biocompatibility. Research and …

Fluorescent amino acids as versatile building blocks for chemical biology

Z Cheng, E Kuru, A Sachdeva, M Vendrell - Nature Reviews Chemistry, 2020 - nature.com
Fluorophores have transformed the way we study biological systems, enabling non-invasive
studies in cells and intact organisms, which increase our understanding of complex …

Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns

WS Horne, TN Grossmann - Nature chemistry, 2020 - nature.com
Proteins have evolved as a variable platform that provides access to molecules with diverse
shapes, sizes and functions. These features have inspired chemists for decades to seek …

Integrating Computation, Experiment, and Machine Learning in the Design of Peptide‐Based Supramolecular Materials and Systems

M Ramakrishnan, A van Teijlingen… - Angewandte Chemie …, 2023 - Wiley Online Library
Interest in peptide‐based supramolecular materials has grown extensively since the 1980s
and the application of computational methods has paralleled this. These methods contribute …

Precise assembly of proteins and carbohydrates for next-generation biomaterials

L Li, G Chen - Journal of the American Chemical Society, 2022 - ACS Publications
The complexity and diversity of biomacromolecules make them a unique class of building
blocks for generating precise assemblies. They are particularly available to a new …

Hollow octadecameric self-assembly of collagen-like peptides

LT Yu, MC Hancu, MAB Kreutzberger… - Journal of the …, 2023 - ACS Publications
The folding of collagen is a hierarchical process that starts with three peptides associating
into the characteristic triple helical fold. Depending on the specific collagen in question …