The immune system is a very diverse system of the host that evolved during evolution to
cope with various pathogens present in the vicinity of environmental surroundings inhabited …

Sepsis is a life-threatening condition and a global disease burden. Today, the
heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated …

Background Early and accurate identification of sepsis patients with high risk of in-hospital
death can help physicians in intensive care units (ICUs) make optimal clinical decisions …

Sepsis was first described by the ancient Greek physicians over 2000 years ago. The
pathophysiology of the disease, however, is still not fully understood and hence the mortality …

OBJECTIVE: Hemophagocytic lymphohistiocytosis is a hyperinflammatory syndrome that
often requires critical care support and remains difficult to diagnose. These guidelines are …

Cells of the innate and adaptive immune systems play a critical role in the host response to
sepsis. Moreover, their accessibility for sampling and their capacity to respond dynamically …

Natural killer (NK) cells are important in innate immunity, first described as guardians for the
detection and clearance of transformed or virus‐infected cells. Later, this cell type was …

Leukocyte recruitment to sites of infection or tissue damage plays a crucial role for the innate
immune response. Chemokine-dependent signaling in immune cells is a very important …

Background: Premature rupture of the membranes (PROM) is the principal risk factor for
neonatal sepsis. Interleukin-6 (IL-6) has been investigated for early diagnosis of neonatal …

Immune cells of the myeloid and lymphoid lineages express Toll-like receptors (TLRs) to
recognize pathogenic components or cellular debris and activate the immune system …