We describe a recently recognized disease entity, limbic-predominant age-related TDP-43
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …

Cognitive impairment associated with aging has emerged as one of the major public health
challenges of our time. Although Alzheimer's disease is the leading cause of clinically …

Inclusions of pathogenic deposits containing TAR DNA-binding protein 43 (TDP-43) are
evident in the brain and spinal cord of patients that present across a spectrum of …

The key pathological hallmarks—extracellular plaques and intracellular neurofibrillary
tangles (NFT)—described by Alois Alzheimer in his seminal 1907 article are still central to …

Alzheimer's disease is a progressive neurodegenerative disease most often associated with
memory deficits and cognitive decline, although less common clinical presentations are …

Liquid–liquid phase separation (LLPS) of proteins underlies the formation of membrane-less
organelles. While it has been recognized for some time that these organelles are of key …

Longitudinal clinical–pathological studies have increasingly recognized the importance of
mixed pathologies (the coexistence of one or more neurodegenerative and cerebrovascular …

Pathological aggregation of the transactive response DNA-binding protein of 43 kDa (TDP-
43) is associated with several neurodegenerative disorders, including ALS, frontotemporal …

Alzheimer's disease, the commonest cause of dementia, is a growing global health concern
with huge implications for individuals and society. In this review, current understanding of …

Background and Objectives Loneliness is common, and its prevalence is rising. The
relationship of loneliness with subsequent dementia and the early preclinical course of …