The classic pathologic hallmarks of Alzheimer's disease (AD) are amyloid plaques and
neurofibrillary tangles (AD neuropathologic changes, or ADNC). However, brains from …

Limbic‐predominant age‐related transactive response DNA‐binding protein 43 (TDP‐43)
encephalopathy neuropathologic change (LATE‐NC) and microvascular pathologies …

Background: Clinicopathological studies have demonstrated that Alzheimer's disease
dementia (ADD) is often accompanied by clinically undetectable comorbid …

To determine the significance of TAR DNA binding protein 43 kDa (TDP-43) pathology in
amyotrophic lateral sclerosis (ALS), we examined the whole brains and spinal cords of 57 …

We examined the relationships between Alzheimer's disease neuropathologic change
(ADNC), Lewy body disease (LBD), and vascular brain injury (VBI) in 2 large autopsy …

Intracellular proteinaceous aggregates (inclusion bodies) are almost always detectable at
autopsy in brains of elderly individuals. Inclusion bodies composed of TDP‐43 and tau …

Objective Primary age‐related tauopathy (PART) refers to tau neurofibrillary tangles
restricted largely to the medial temporal lobe in the absence of significant beta‐amyloid …

Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-
NC) is most often seen in the oldest-old (≥ 90 years of age) but can also be present in the …

Figure 1 TDP-43 immunoreactive inclusions can be found in many different
neurodegenerative diseases. Currently TDP-43 proteinopathies are divided into primary …

The discovery that aggregated transactive response DNA-binding protein 43 kDa (TDP-43)
is the major component of pathological ubiquitinated inclusions in amyotrophic lateral …