miRNA: a promising therapeutic target in cancer

A Menon, N Abd-Aziz, K Khalid, CL Poh… - International journal of …, 2022 - mdpi.com
microRNAs are small non-coding RNAs that regulate several genes post-transcriptionally by
complementarity pairing. Since discovery, they have been reported to be involved in a …

The potential role of miRNAs in the pathogenesis of adrenocortical carcinoma-A focus on signaling pathways interplay

HM Midan, GK Helal, AI Abulsoud, SS Elshaer… - … -Research and Practice, 2023 - Elsevier
Adrenocortical carcinoma (ACC) is a highly malignant infrequent tumor with a dismal
prognosis. microRNAs (miRNAs, miRs) are crucial in post-transcriptional gene expression …

Non-coding RNAs in lung cancer: molecular mechanisms and clinical applications

Y Liu, W Ding, J Wang, X Ao, J Xue - Frontiers in oncology, 2023 - frontiersin.org
Lung cancer (LC) is a heterogeneous disease with high malignant degree, rapid growth,
and early metastasis. The clinical outcomes of LC patients are generally poor due to the …

The miRNA–target interactions: An underestimated intricacy

C Diener, A Keller, E Meese - Nucleic Acids Research, 2024 - academic.oup.com
MicroRNAs (miRNAs) play indispensable roles in posttranscriptional gene regulation. Their
cellular regulatory impact is determined not solely by their sheer number, which likely …

Safety and activity of the first-in-class locked nucleic acid (LNA) miR-221 selective inhibitor in refractory advanced cancer patients: A first-in-human, phase 1, open …

P Tassone, MT Di Martino, M Arbitrio, L Fiorillo… - Journal of hematology & …, 2023 - Springer
Background We developed a 13-mer locked nucleic acid (LNA) inhibitor of miR-221 (LNA-i-
miR-221) with a full phosphorothioate (PS)-modified backbone. This agent downregulated …

Human umbilical cord mesenchymal stem cells derived exosome shuttling mir-129-5p attenuates inflammatory bowel disease by inhibiting ferroptosis

Z Wei, S Hang, DK Wiredu Ocansey, Z Zhang… - Journal of …, 2023 - Springer
Background Ferroptosis, a unique form of non-apoptotic cell death, is dependent on iron and
lipoperoxidation, and has been shown to be associated with the pathogenesis of …

SGLT2 inhibitor empagliflozin downregulates miRNA-34a-5p and targets GREM2 to inactivate hepatic stellate cells and ameliorate non-alcoholic fatty liver disease …

Y Shen, L Cheng, M Xu, W Wang, Z Wan, H Xiong… - Metabolism, 2023 - Elsevier
Background and rationale Activation of hepatic stellate cells (HSCs), the central event of
fibrosis, indicates the severe stage of non-alcoholic fatty liver disease (NAFLD). MicroRNAs …

Point‐of‐Care Testing for the Detection of MicroRNAs: Towards Liquid Biopsy on a Chip

G Moro, CD Fratte, N Normanno… - Angewandte Chemie …, 2023 - Wiley Online Library
Abstract Point‐of‐care (PoC) testing is revolutionizing the healthcare sector improving
patient care in daily hospital practice and allowing reaching even remote geographical …

Innovative approaches in transforming microRNAs into therapeutic tools

AFA Samad, MF Kamaroddin - Wiley Interdisciplinary Reviews …, 2023 - Wiley Online Library
MicroRNA (miRNA) is regarded as a prominent genetic regulator, as it can fine‐tune an
entire biological pathway by targeting multiple target genes. This characteristic makes …

Gender differences in the pathogenesis and risk factors of hepatocellular carcinoma

R Nevola, G Tortorella, V Rosato, L Rinaldi, S Imbriani… - Biology, 2023 - mdpi.com
Simple Summary Significant gender disparities have been highlighted in the incidence,
aggressiveness, and prognosis of HCC. A different epidemiological distribution of the risk …