miRNA: a promising therapeutic target in cancer
microRNAs are small non-coding RNAs that regulate several genes post-transcriptionally by
complementarity pairing. Since discovery, they have been reported to be involved in a …
complementarity pairing. Since discovery, they have been reported to be involved in a …
The potential role of miRNAs in the pathogenesis of adrenocortical carcinoma-A focus on signaling pathways interplay
Adrenocortical carcinoma (ACC) is a highly malignant infrequent tumor with a dismal
prognosis. microRNAs (miRNAs, miRs) are crucial in post-transcriptional gene expression …
prognosis. microRNAs (miRNAs, miRs) are crucial in post-transcriptional gene expression …
Non-coding RNAs in lung cancer: molecular mechanisms and clinical applications
Y Liu, W Ding, J Wang, X Ao, J Xue - Frontiers in oncology, 2023 - frontiersin.org
Lung cancer (LC) is a heterogeneous disease with high malignant degree, rapid growth,
and early metastasis. The clinical outcomes of LC patients are generally poor due to the …
and early metastasis. The clinical outcomes of LC patients are generally poor due to the …
The miRNA–target interactions: An underestimated intricacy
MicroRNAs (miRNAs) play indispensable roles in posttranscriptional gene regulation. Their
cellular regulatory impact is determined not solely by their sheer number, which likely …
cellular regulatory impact is determined not solely by their sheer number, which likely …
Safety and activity of the first-in-class locked nucleic acid (LNA) miR-221 selective inhibitor in refractory advanced cancer patients: A first-in-human, phase 1, open …
Background We developed a 13-mer locked nucleic acid (LNA) inhibitor of miR-221 (LNA-i-
miR-221) with a full phosphorothioate (PS)-modified backbone. This agent downregulated …
miR-221) with a full phosphorothioate (PS)-modified backbone. This agent downregulated …
Human umbilical cord mesenchymal stem cells derived exosome shuttling mir-129-5p attenuates inflammatory bowel disease by inhibiting ferroptosis
Z Wei, S Hang, DK Wiredu Ocansey, Z Zhang… - Journal of …, 2023 - Springer
Background Ferroptosis, a unique form of non-apoptotic cell death, is dependent on iron and
lipoperoxidation, and has been shown to be associated with the pathogenesis of …
lipoperoxidation, and has been shown to be associated with the pathogenesis of …
SGLT2 inhibitor empagliflozin downregulates miRNA-34a-5p and targets GREM2 to inactivate hepatic stellate cells and ameliorate non-alcoholic fatty liver disease …
Y Shen, L Cheng, M Xu, W Wang, Z Wan, H Xiong… - Metabolism, 2023 - Elsevier
Background and rationale Activation of hepatic stellate cells (HSCs), the central event of
fibrosis, indicates the severe stage of non-alcoholic fatty liver disease (NAFLD). MicroRNAs …
fibrosis, indicates the severe stage of non-alcoholic fatty liver disease (NAFLD). MicroRNAs …
Point‐of‐Care Testing for the Detection of MicroRNAs: Towards Liquid Biopsy on a Chip
G Moro, CD Fratte, N Normanno… - Angewandte Chemie …, 2023 - Wiley Online Library
Abstract Point‐of‐care (PoC) testing is revolutionizing the healthcare sector improving
patient care in daily hospital practice and allowing reaching even remote geographical …
patient care in daily hospital practice and allowing reaching even remote geographical …
Innovative approaches in transforming microRNAs into therapeutic tools
AFA Samad, MF Kamaroddin - Wiley Interdisciplinary Reviews …, 2023 - Wiley Online Library
MicroRNA (miRNA) is regarded as a prominent genetic regulator, as it can fine‐tune an
entire biological pathway by targeting multiple target genes. This characteristic makes …
entire biological pathway by targeting multiple target genes. This characteristic makes …
Gender differences in the pathogenesis and risk factors of hepatocellular carcinoma
Simple Summary Significant gender disparities have been highlighted in the incidence,
aggressiveness, and prognosis of HCC. A different epidemiological distribution of the risk …
aggressiveness, and prognosis of HCC. A different epidemiological distribution of the risk …