The lens epithelium as a major determinant in the development, maintenance, and regeneration of the crystalline lens

Z Liu, S Huang, Y Zheng, T Zhou, L Hu, L Xiong… - Progress in retinal and …, 2023 - Elsevier
The crystalline lens is a transparent and refractive biconvex structure formed by lens
epithelial cells (LECs) and lens fibers. Lens opacity, also known as cataracts, is the leading …

Diversity in connexin biology

SA Lucaciu, SE Leighton, A Hauser, R Yee… - Journal of Biological …, 2023 - ASBMB
Over 35 years ago the cell biology community was introduced to connexins as the subunit
employed to assemble semicrystalline clusters of intercellular channels that had been well …

Effect of lipid oxidation on the channel properties of Cx26 hemichannels: a molecular dynamics study

MC Oliveira, RM Cordeiro, A Bogaerts - Archives of Biochemistry and …, 2023 - Elsevier
Intercellular communication plays a crucial role in cancer, as well as other diseases, such as
inflammation, tissue degeneration, and neurological disorders. One of the proteins …

Gap junction Delta-2b (gjd2b/Cx35.1) depletion causes hyperopia and visual-motor deficiencies in the zebrafish

CA Brown-Panton, S Sabour, GSO Zoidl… - Frontiers in Cell and …, 2023 - frontiersin.org
The zebrafish is a powerful model to investigate the developmental roles of electrical
synapses because many signaling pathways that regulate the development of the nervous …

Levels and modifications of both lens fiber cell connexins are affected in connexin mutant mice

O Jara, PJ Minogue, VM Berthoud, EC Beyer - Cells, 2022 - mdpi.com
In the lens, cell homeostasis and transparency are supported by intercellular communication
facilitated by the channels formed of connexin46 (Cx46) and connexin50 (Cx50). Mutations …