Chemical approaches to cryopreservation

KA Murray, MI Gibson - Nature Reviews Chemistry, 2022 - nature.com
Cryopreservation of cells and biologics underpins all biomedical research from routine
sample storage to emerging cell-based therapies, as well as ensuring cell banks provide …

Ice inhibition for cryopreservation: materials, strategies, and challenges

T Chang, G Zhao - Advanced Science, 2021 - Wiley Online Library
Cryopreservation technology has developed into a fundamental and important supporting
method for biomedical applications such as cell‐based therapeutics, tissue engineering …

Bioinspired ice-binding materials for tissue and organ cryopreservation

Z Liu, X Zheng, J Wang - Journal of the American Chemical …, 2022 - ACS Publications
Cryopreservation of tissues and organs can bring transformative changes to medicine and
medical science. In the past decades, limited progress has been achieved, although …

The atomistic details of the ice recrystallisation inhibition activity of PVA

F Bachtiger, TR Congdon, C Stubbs, MI Gibson… - Nature …, 2021 - nature.com
Understanding the ice recrystallisation inhibition (IRI) activity of antifreeze biomimetics is
crucial to the development of the next generation of cryoprotectants. In this work, we bring …

Dual cryoprotective strategies for ice-binding and stabilizing of frozen seafood: A review

S Zhu, J Yu, X Chen, Q Zhang, X Cai, Y Ding… - Trends in Food Science …, 2021 - Elsevier
Background Freezing-induced damages on seafood are pervasive problems that result from
physical and biochemical changes during the freezing process. The formation of ice crystals …

The role of trifunctional cryoprotectants in the frozen storage of aquatic foods: Recent developments and future recommendations

J Tian, N Walayat, Y Ding, J Liu - Comprehensive reviews in …, 2022 - Wiley Online Library
Freeze‐induced changes including protein denaturation, ice crystals formation and lipid
oxidation are mainly responsible for the quality deterioration persistent in aquatic foods …

Control of ice crystal nucleation and growth during the food freezing process

G Jia, Y Chen, AD Sun, V Orlien - Comprehensive Reviews in …, 2022 - Wiley Online Library
Freezing can maintain a low‐temperature environment inside food, reducing water activity
and preventing microorganism growth. However, when ice crystals are large, present in high …

Molecular characteristics and structure–activity relationships of food-derived bioactive peptides

FJ Yang, C Xu, MC Huang, Y Qian, XX Cai… - Journal of Integrative …, 2021 - Elsevier
Peptides are functional active fragments of proteins which can provide nutrients needed for
human growth and development, and they also have unique physiological activity …

Nanoscopy of single antifreeze proteins reveals that reversible ice binding is sufficient for ice recrystallization inhibition but not thermal hysteresis

RP Tas, MMRM Hendrix… - Proceedings of the …, 2023 - National Acad Sciences
Antifreeze proteins (AFPs) bind ice to reduce freezing temperatures and arrest ice crystal
ripening, making AFPs essential for the survival of many organisms in ice-laden …

Control strategies of ice nucleation, growth, and recrystallization for cryopreservation

M Lin, H Cao, J Li - Acta Biomaterialia, 2023 - Elsevier
The cryopreservation of biomaterials is fundamental to modern biotechnology and
biomedicine, but the biggest challenge is the formation of ice, resulting in fatal cryoinjury to …