This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

DNA hypomethylation was the initial epigenetic abnormality recognized in human tumors.
However, for several decades after its independent discovery by two laboratories in 1983, it …

Formation of γ-H2AX in response to DNA double stranded breaks (DSBs) provides the basis
for a sensitive assay of DNA damage in human biopsies. The review focuses on the …

The expression of the renoprotective antiaging gene Klotho is decreased in uremia. Recent
studies suggest that Klotho may be a tumor suppressor, and its expression may be …

Epigenetic inactivation of pivotal genes involved in correct cell growth is a hallmark of
human pathologies, in particular cancer. These epigenetic mechanisms, including crosstalk …

Abstract Background Tyrosine kinase inhibitors (TKIs) such as sunitinib are multitarget
antiangiogenic agents in clear cell renal cell carcinoma (ccRCC). They are widely used in …

DNA methylation is an epigenetic modification involved in gene expression regulation. In
cancer, the DNA methylation pattern becomes aberrant, causing an array of tumor …

Epigenetic regulation of gene expression is well known mechanism that regulates cellular
senescence of cancer cells. Here we show that inhibition of DNA methyltransferases …

DNA methylation plays an important role in regulating normal development and
carcinogenesis. Current understanding of the biological roles of DNA methylation is limited …

Recent studies have demonstrated that human astrocytes and fibroblasts can be directly
converted into functional neurons by small molecules. However, fibroblasts, as a potentially …