Accumulating findings during the past decades have demonstrated that the hypothalamic
arcuate kisspeptin neurons are supposed to be responsible for pulsatile release of …

Gonadotropin-releasing hormone (GnRH) is the master regulator of the hypothalamic-
pituitary-gonadal (HPG) axis, and therefore of fertility and reproduction. The release pattern …

The neural mechanisms generating pulsatile GnRH release from the median eminence (ME)
remain unclear. Studies undertaken in the mouse demonstrate that GnRH neurons extend …

Agouti-related peptide (AgRP) neurons, which relay information from peripheral metabolic
signals, may constitute a key central regulator of reproduction. Given that AgRP inhibits …

Substance P (SP) and neurokinin A (NKA), encoded by TAC1/Tac1 gene are members of
the tachykinin family, which exert their neuromodulatory roles in vertebrate reproduction. In …

Animal models remain essential to understand the fundamental mechanisms of physiology
and pathology. Particularly, the complex and dynamic nature of neuroendocrine cells of the …

Introduction: Postweaning social isolation (PWSI) in rodents is an advanced psychosocial
stress model in early life. Some psychosocial stress, such as restrain and isolation, disrupts …

In this study, we describe in detail the anatomy of nuclei involved in seasonal fertility
regulation (SFR) in ewes. For this purpose, the intergeniculate leaflet of the visual thalamus …

Sheep have been an important animal for both academic and basic sciences education, with
a positive impact on the public health sector and, subsequently, One Health. This review …

Multiple factors influence the timing and commencement of puberty in mammals and
gonadotropin-releasing hormone (GnRH) is an important one of those. GnRH is a …