Background The efficacy of screening for colorectal cancer using a simple blood-based
assay for the detection of tumor cells disseminated in the circulation at an early stage of the …

We have reported earlier that ectopic expression of mouse double minute-2 (MDM2)
induces G1 arrest in normal cells. To explain occasional overexpression of MDM2 in cancer …

The burden of occult malignant cells which remains after a course of treatment that has
resulted in clinical remission is referred to as minimal residual disease (MRD). MRD is …

Developments in breast cancer biology over the last year have brought molecular medicine
closer to the clinic. Within the past year, two major advances have taken place. First …

Background: Metastatic breast cancer (MBC) is incurable and any treatment is considered
palliative. Occult dissemination of tumor cells is responsible for recurrent MBC in patients …

I first thought about metabolic regulation while I was a postdoctoral fellow. We demonstrated
that oxalacetate inhibits succinic dehydrogenase, several steps back in the Krebs cycle (4). I …

Microarray technologies are capable of simultaneously measuring the signals for thousands
of messenger RNAs and large numbers of proteins from single samples. Arrays are now …

The major cause for plaque instability in atherosclerotic disease is neoangiogenic
revascularization, but the factors controlling this process remain only partly understood …

We evaluated the potential utility of occult circulating tumor DNA as a molecular marker of
disease in subjects previously diagnosed with breast cancer. Using 24 microsatellite …

Objetivo: el objetivo de este estudio fue comparar, en individuos con obesidad, la expresión
de genes que regulan los procesos de adipogénesis (PLIN1, ADRB3 y PPARg2) y el …