Transgenic mouse models have provided evidence that activation of the zinc-finger
transcription factor GLI1 by Hedgehog (Hh)-signalling is a key step in the initiation of the …

Introduction Sepsis is a complex immunological response to infection characterized by early
hyper-inflammation followed by severe and protracted immunosuppression, suggesting that …

Sonic hedgehog (Shh) binds to its receptor patched (PTCH), leading to the activation and
repression of target genes via the GLI family of zinc-finger transcription factors. Deregulation …

Owing to the dynamic nature of the transcriptome, gene expression profiling is a promising
tool for discovery of disease-related genes and biological pathways. In the present study, we …

The homeobox gene superfamily encodes transcription factors that act as master regulators
of development through their ability to activate or repress a diverse range of downstream …

After a large-scale nuclear accident or an attack with an improvised nuclear device, rapid
biodosimetry would be needed for triage. As a possible means to address this need, we …

Expression profiling has demonstrated that transcriptomes of primary malignancies differ
from those in normal tissue. It is unknown, however, whether there exist “surrogate” …

Background—Although many genetic epidemiology and biomarker studies have been
conducted to examine associations of genetic variants and circulating proteins with …

The increased life expectancy and the expansion of the elderly population are stimulating
research into aging. Aging may be viewed as a multifactorial process that results from the …

Background Previous work has demonstrated the potential for peripheral blood (PB) gene
expression profiling for the detection of disease or environmental exposures. Methods and …