Mitochondria play a central role in the survival and death of neurons. The detailed
bioenergetic mechanisms by which isolated mitochondria generate ATP, sequester Ca2+ …

Partially reduced forms of oxygen are produced in the brain during cellular respiration and,
at accelerated rates, during brain insults. The most reactive forms, such as the hydroxyl …

Activation of apoptosis is associated with generation of reactive oxygen species. The
present research shows that superoxide is produced by mitochondria isolated from apoptotic …

Apoptosis is now recognized as a normal feature in the development of the nervous system
and may also play a role in neurodegenerative diseases and aging. This phenomenon has …

Exposure of mammalian cells to oxidant stress causes early (iron catalysed) lysosomal
rupture followed by apoptosis or necrosis. Enhanced intracellular production of reactive …

Primary dissociated neuronal cultures have been intensively exploited for the past 15 years
as model systems to investigate excitotoxic neuronal degeneration. Even this simplified …

Focal adhesion kinase (FAK) has an anti-apoptotic role in anchorage-dependent cells via an
unknown mechanism. To elucidate the role of FAK in anti-apoptosis, we have established …

Channels formed by the transient receptor potential (TRP) family of proteins have a variety of
physiological functions. Here we report that two members of the TRP cation channel (TRPC) …

The fundamental physiological function of native cellular prion (PrPC) remains unknown.
Herein, the most salient observations as regards prion physiology are critically evaluated …

Iron‐dependent oxidative stress, elevated levels of iron and of monoamine oxidase (MAO)‐
B activity, and depletion of antioxidants in the brain may be major pathogenic factors in …