Engineered living materials for advanced diseases therapy

X Dong, W Wu, P Pan, XZ Zhang - Advanced Materials, 2023 - Wiley Online Library
Natural living materials serving as biotherapeutics exhibit great potential for treating various
diseases owing to their immunoactivity, tissue targeting, and other biological activities. In this …

Rewiring photosynthetic electron transport chains for solar energy conversion

JM Lawrence, RM Egan, T Hoefer… - Nature Reviews …, 2023 - nature.com
Photosynthetic organisms have evolved versatile electron transport chains that efficiently
convert solar energy into chemical energy. Researchers can engineer these electron …

[HTML][HTML] Plant glycoengineering for designing next-generation vaccines and therapeutic proteins

R Strasser - Biotechnology Advances, 2023 - Elsevier
Protein glycosylation has a huge impact on biological processes in all domains of life. The
type of glycan present on a recombinant glycoprotein depends on protein intrinsic features …

[HTML][HTML] An oligosaccharyltransferase from Leishmania donovani increases the N-glycan occupancy on plant-produced IgG1

G Beihammer, J König-Beihammer… - Frontiers in Plant …, 2023 - frontiersin.org
N-Glycosylation of immunoglobulin G1 (IgG1) at the heavy chain Fc domain (Asn297) plays
an important role for antibody structure and effector functions. While numerous recombinant …

A genome‐edited N. benthamiana line for industrial‐scale production of recombinant glycoproteins with targeted N‐glycosylation

B Kogelmann, S Melnik, M Bogner… - Biotechnology …, 2024 - Wiley Online Library
Control over glycosylation is an important quality parameter in recombinant protein
production. Here, we demonstrate the generation of a marker‐free genome edited Nicotiana …

[HTML][HTML] Product safety aspects of plant molecular farming

JF Buyel - Frontiers in Bioengineering and Biotechnology, 2023 - frontiersin.org
Plant molecular farming (PMF) has been promoted since the 1990s as a rapid, cost-effective
and (most of all) safe alternative to the cultivation of bacteria or animal cells for the …

[HTML][HTML] Glyco engineered pentameric SARS-CoV-2 IgMs show superior activities compared to IgG1 orthologues

S Kallolimath, R Palt, E Föderl-Höbenreich… - Frontiers in …, 2023 - frontiersin.org
Immunoglobulin M (IgM) is the largest antibody isotype with unique features like extensive
glycosylation and oligomerization. Major hurdles in characterizing its properties are …

[HTML][HTML] Green biologics: harnessing the power of plants to produce pharmaceuticals

G Zahmanova, AAA Aljabali, K Takova… - International Journal of …, 2023 - mdpi.com
Plants are increasingly used for the production of high-quality biological molecules for use
as pharmaceuticals and biomaterials in industry. Plants have proved that they can produce …

Plant virus‐derived nanoparticles decorated with genetically encoded SARS‐CoV‐2 nanobodies display enhanced neutralizing activity

F Merwaiss, E Lozano‐Sanchez… - Plant Biotechnology …, 2024 - Wiley Online Library
Viral nanoparticles (VNPs) are a new class of virus‐based formulations that can be used as
building blocks to implement a variety of functions of potential interest in biotechnology and …

[HTML][HTML] Performance of plant-produced RBDs as SARS-CoV-2 diagnostic reagents: a tale of two plant platforms

M Santoni, N Gutierrez-Valdes, D Pivotto… - Frontiers in Plant …, 2024 - frontiersin.org
The COVID-19 pandemic has underscored the need for rapid and cost-effective diagnostic
tools. Serological tests, particularly those measuring antibodies targeting the receptor …