[HTML][HTML] Epigenetic modulation of antitumor immunity for improved cancer immunotherapy
Epigenetic mechanisms play vital roles not only in cancer initiation and progression, but also
in the activation, differentiation and effector function (s) of immune cells. In this review, we …
in the activation, differentiation and effector function (s) of immune cells. In this review, we …
Organometallic anti-tumor agents: targeting from biomolecules to dynamic bioprocesses
The great clinical success of cisplatin and its derivatives has convinced people that metal
complexes could play a more significant role in human cancer therapy. However, targeting …
complexes could play a more significant role in human cancer therapy. However, targeting …
Pan-cancer analysis identifies tumor-specific antigens derived from transposable elements
Cryptic promoters within transposable elements (TEs) can be transcriptionally reactivated in
tumors to create new TE-chimeric transcripts, which can produce immunogenic antigens. We …
tumors to create new TE-chimeric transcripts, which can produce immunogenic antigens. We …
Cancer multidrug-resistance reversal by ABCB1 inhibition: A recent update
K Engle, G Kumar - European Journal of Medicinal Chemistry, 2022 - Elsevier
Chemotherapy is one of the most common treatments for cancer that uses one or more anti-
cancer drugs as a part of the standardized chemotherapy regimen. Cytotoxic chemicals …
cancer drugs as a part of the standardized chemotherapy regimen. Cytotoxic chemicals …
Prostate cancer reactivates developmental epigenomic programs during metastatic progression
MM Pomerantz, X Qiu, Y Zhu, DY Takeda, W Pan… - Nature …, 2020 - nature.com
Epigenetic processes govern prostate cancer (PCa) biology, as evidenced by the
dependency of PCa cells on the androgen receptor (AR), a prostate master transcription …
dependency of PCa cells on the androgen receptor (AR), a prostate master transcription …
Epigenetic plasticity and the hallmarks of cancer
WA Flavahan, E Gaskell, BE Bernstein - Science, 2017 - science.org
BACKGROUND Chromatin is the essential medium through which transcription factors,
signaling pathways, and other cues alter gene activity and cellular phenotypes. It assumes …
signaling pathways, and other cues alter gene activity and cellular phenotypes. It assumes …
[HTML][HTML] Triple negative breast cancer (TNBC): Non-genetic tumor heterogeneity and immune microenvironment: Emerging treatment options
Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by extensive
intra-tumoral heterogeneity, and frequently develops resistance to therapies. Tumor …
intra-tumoral heterogeneity, and frequently develops resistance to therapies. Tumor …
The emerging role of epigenetic therapeutics in immuno-oncology
MJ Topper, M Vaz, KA Marrone, JR Brahmer… - Nature Reviews …, 2020 - nature.com
The past decade has seen the emergence of immunotherapy as a prime approach to cancer
treatment, revolutionizing the management of many types of cancer. Despite the promise of …
treatment, revolutionizing the management of many types of cancer. Despite the promise of …
[HTML][HTML] Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling
Background In recent years the Illumina HumanMethylation450 (HM450) BeadChip has
provided a user-friendly platform to profile DNA methylation in human samples. However …
provided a user-friendly platform to profile DNA methylation in human samples. However …
Targeting the cancer epigenome for therapy
Next-generation sequencing has revealed that more than 50% of human cancers harbour
mutations in enzymes that are involved in chromatin organization. Tumour cells not only are …
mutations in enzymes that are involved in chromatin organization. Tumour cells not only are …