[HTML][HTML] Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling
Background In recent years the Illumina HumanMethylation450 (HM450) BeadChip has
provided a user-friendly platform to profile DNA methylation in human samples. However …
provided a user-friendly platform to profile DNA methylation in human samples. However …
[HTML][HTML] Multi-omics approaches for biomarker discovery in early ovarian cancer diagnosis
Y Xiao, M Bi, H Guo, M Li - EBioMedicine, 2022 - thelancet.com
Ovarian cancer (OC) is a heterogeneous disease with the highest mortality rate and the
poorest prognosis among gynecological malignancies. Because of the absence of specific …
poorest prognosis among gynecological malignancies. Because of the absence of specific …
Targeting the cancer epigenome for therapy
Next-generation sequencing has revealed that more than 50% of human cancers harbour
mutations in enzymes that are involved in chromatin organization. Tumour cells not only are …
mutations in enzymes that are involved in chromatin organization. Tumour cells not only are …
Prevalence of homologous recombination–related gene mutations across multiple cancer types
AL Heeke, MJ Pishvaian, F Lynce, J Xiu… - JCO precision …, 2018 - ascopubs.org
Purpose The prevalence of homologous recombination DNA damage repair (HR-DDR)
deficiencies among all tumor lineages is not well characterized. Therapy directed toward …
deficiencies among all tumor lineages is not well characterized. Therapy directed toward …
The DNA methylation landscape in cancer
As one of the most abundant and well-studied epigenetic modifications, DNA methylation
plays an essential role in normal development and cellular biology. Global alterations to the …
plays an essential role in normal development and cellular biology. Global alterations to the …
Histone modifications and cancer
JE Audia, RM Campbell - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
Histone posttranslational modifications represent a versatile set of epigenetic marks
involved not only in dynamic cellular processes, such as transcription and DNA repair, but …
involved not only in dynamic cellular processes, such as transcription and DNA repair, but …
[HTML][HTML] Gene body methylation in cancer: molecular mechanisms and clinical applications
Q Wang, F Xiong, G Wu, W Liu, J Chen, B Wang… - Clinical …, 2022 - Springer
DNA methylation is an important epigenetic mechanism that regulates gene expression. To
date, most DNA methylation studies have focussed on CpG islands in the gene promoter …
date, most DNA methylation studies have focussed on CpG islands in the gene promoter …
[HTML][HTML] Epigenetic therapy ties MYC depletion to reversing immune evasion and treating lung cancer
MJ Topper, M Vaz, KB Chiappinelli, CEDS Shields… - Cell, 2017 - cell.com
Combining DNA-demethylating agents (DNA methyltransferase inhibitors [DNMTis]) with
histone deacetylase inhibitors (HDACis) holds promise for enhancing cancer immune …
histone deacetylase inhibitors (HDACis) holds promise for enhancing cancer immune …
Evaluation of post-translational modifications in histone proteins: A review on histone modification defects in developmental and neurological disorders
S Ramazi, A Allahverdi, J Zahiri - Journal of biosciences, 2020 - Springer
Post-translational modification (PTM) in histone proteins is a covalent modification which
mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation …
mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation …
Transcription factors as readers and effectors of DNA methylation
Recent technological advances have made it possible to decode DNA methylomes at single-
base-pair resolution under various physiological conditions. Many aberrant or differentially …
base-pair resolution under various physiological conditions. Many aberrant or differentially …