CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats-associated protein
9) shows the opportunity to treat a diverse array of untreated various genetic and …

Simple Summary Hemangiosarcoma is a mesenchymal neoplasm that originates in the
endothelial cells of blood vessels. According to the location of origin, they can be classified …

Naturally occurring canine cancers have remarkable similarities to their human counterparts.
To better understand these similarities, we investigated 671 client-owned dogs from 96 …

Spontaneous tumors in canines share significant genetic and histological similarities with
human tumors, positioning them as valuable models to guide drug development. However …

ABSTRACT PD-1 checkpoint inhibitors have revolutionized the treatment of patients with
different cancer histologies including melanoma, renal cell carcinoma, and non-small cell …

Pet dogs develop spontaneous cancers at a rate estimated to be five times higher than that
of humans, providing a unique opportunity to study disease biology and evaluate novel …

The tumor-immune interplay represents a dynamic series of events executed by cellular and
soluble participants that either promote or inhibit successful tumor formation and growth …

7 Nuclear Transport Inhibitors Page 1 7 Nuclear Transport Inhibitors CHERYL LONDON* Tufts
University, North Grafton, Massachusetts, USA Introduction: Regulation of Nuclear Transport The …

The microbiome has clearly been established as a cutting-edge field in tumor immunology
and immunotherapy. Growing evidence supports the role of the microbiome in immune …

Background About 20% of breast cancers in humans are basal-like, a subtype that is often
triple-negative and difficult to treat. An effective translational model for basal-like breast …