Calcitriol, the hormonally active form of vitamin D, is being evaluated in clinical trials as an
anti-cancer agent. Calcitriol exerts multiple anti-proliferative, pro-apoptotic, and pro …

Acetylsalicylic acid (aspirin) is a prototypic cyclooxygenase (COX) inhibitor. It was
synthesized serendipitously from a natural compound, ie, salicylic acid, with known …

Cellular signaling pathways involved in the maintenance of the equilibrium between cell
proliferation and apoptosis have emerged as rational targets that can be exploited in the …

Abstract Hydrogen sulfide (H2S), a metabolic end product of sulfate‐reducing bacteria,
represents a genotoxic insult to the colonic epithelium, which may also be linked with …

Hyperleptinemia is a common feature of obese women who have a higher risk of
endometrial cancer than women with normal weights, and epidemiologic studies have …

One of the most intriguing enzymes of sphingolipid biology is acid sphingomyelinase
(ASMase). In a phospholipase C reaction, ASMase catalyzes the cleavage of the …

Various epidemiological studies have shown an aetiological link between vitamin D
deficiency and cancer incidence. The active metabolite of vitamin D, 1, 25-dihydroxyvitamin …

Chinese red yeast rice (RYR) is a food herb made by fermenting Monascus purpureus Went
yeast with white rice. RYR contains a mixture of monacolins, one of which—monacolin K …

The present study was aimed to coencapsulate methotrexate (MTX) and aceclofenac (ACL)
in fucose anchored lipid–polymer hybrid nanoparticles (Fu-LPHNPs) to achieve target …

Omega-3 fatty acids (ω3-FA) were shown to attenuate growth and induce apoptosis in a
variety of human cancer cell lines derived from colonic, pancreatic, prostate, and breast …