DREADDS: Use and application in behavioral neuroscience.

KS Smith, DJ Bucci, BW Luikart… - Behavioral …, 2016 - psycnet.apa.org
Technological advances over the last decade are changing the face of behavioral
neuroscience research. Here we review recent work on the use of one such transformative …

The use of chemogenetics in behavioural neuroscience: receptor variants, targeting approaches and caveats

EJ Campbell, NJ Marchant - British journal of pharmacology, 2018 - Wiley Online Library
The last decade has seen major advances in neuroscience tools allowing us to selectively
modulate cellular pathways in freely moving animals. Chemogenetic approaches such as …

[HTML][HTML] An open resource for non-human primate optogenetics

S Tremblay, L Acker, A Afraz, DL Albaugh, H Amita… - Neuron, 2020 - cell.com
Optogenetics has revolutionized neuroscience in small laboratory animals, but its effect on
animal models more closely related to humans, such as non-human primates (NHPs), has …

[HTML][HTML] Fast recurrent processing via ventrolateral prefrontal cortex is needed by the primate ventral stream for robust core visual object recognition

K Kar, JJ DiCarlo - Neuron, 2021 - cell.com
Distributed neural population spiking patterns in macaque inferior temporal (IT) cortex that
support core object recognition require additional time to develop for specific," late-solved" …

[HTML][HTML] Dopamine neuron-specific optogenetic stimulation in rhesus macaques

WR Stauffer, A Lak, A Yang, M Borel, O Paulsen… - Cell, 2016 - cell.com
Optogenetic studies in mice have revealed new relationships between well-defined neurons
and brain functions. However, there are currently no means to achieve the same cell-type …

A robust ex vivo experimental platform for molecular-genetic dissection of adult human neocortical cell types and circuits

JT Ting, B Kalmbach, P Chong, R De Frates… - Scientific reports, 2018 - nature.com
The powerful suite of available genetic tools is driving tremendous progress in
understanding mouse brain cell types and circuits. However, the degree of conservation in …

PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation

Y Nagai, E Kikuchi, W Lerchner, K Inoue, B Ji… - Nature …, 2016 - nature.com
The rostromedial caudate (rmCD) of primates is thought to contribute to reward value
processing, but a causal relationship has not been established. Here we use an inhibitory …

Rapid molecular profiling of defined cell types using viral TRAP

AR Nectow, MV Moya, MI Ekstrand, A Mousa… - Cell reports, 2017 - cell.com
Translational profiling methodologies enable the systematic characterization of cell types in
complex tissues, such as the mammalian brain, where neuronal isolation is exceptionally …

Advances in optogenetic and chemogenetic methods to study brain circuits in non-human primates

A Galvan, MJ Caiola, DL Albaugh - Journal of Neural Transmission, 2018 - Springer
Over the last 10 years, the use of opto-and chemogenetics to modulate neuronal activity in
research applications has increased exponentially. Both techniques involve the genetic …

Chemogenetic inactivation reveals the inhibitory control function of the prefronto-striatal pathway in the macaque brain

M Oguchi, S Tanaka, X Pan, T Kikusui… - Communications …, 2021 - nature.com
The lateral prefrontal cortex (LPFC) has a strong monosynaptic connection with the caudate
nucleus (CdN) of the striatum. Previous human MRI studies have suggested that this LPFC …