DREADDS: Use and application in behavioral neuroscience.
Technological advances over the last decade are changing the face of behavioral
neuroscience research. Here we review recent work on the use of one such transformative …
neuroscience research. Here we review recent work on the use of one such transformative …
The use of chemogenetics in behavioural neuroscience: receptor variants, targeting approaches and caveats
EJ Campbell, NJ Marchant - British journal of pharmacology, 2018 - Wiley Online Library
The last decade has seen major advances in neuroscience tools allowing us to selectively
modulate cellular pathways in freely moving animals. Chemogenetic approaches such as …
modulate cellular pathways in freely moving animals. Chemogenetic approaches such as …
[HTML][HTML] An open resource for non-human primate optogenetics
Optogenetics has revolutionized neuroscience in small laboratory animals, but its effect on
animal models more closely related to humans, such as non-human primates (NHPs), has …
animal models more closely related to humans, such as non-human primates (NHPs), has …
[HTML][HTML] Fast recurrent processing via ventrolateral prefrontal cortex is needed by the primate ventral stream for robust core visual object recognition
K Kar, JJ DiCarlo - Neuron, 2021 - cell.com
Distributed neural population spiking patterns in macaque inferior temporal (IT) cortex that
support core object recognition require additional time to develop for specific," late-solved" …
support core object recognition require additional time to develop for specific," late-solved" …
[HTML][HTML] Dopamine neuron-specific optogenetic stimulation in rhesus macaques
Optogenetic studies in mice have revealed new relationships between well-defined neurons
and brain functions. However, there are currently no means to achieve the same cell-type …
and brain functions. However, there are currently no means to achieve the same cell-type …
A robust ex vivo experimental platform for molecular-genetic dissection of adult human neocortical cell types and circuits
JT Ting, B Kalmbach, P Chong, R De Frates… - Scientific reports, 2018 - nature.com
The powerful suite of available genetic tools is driving tremendous progress in
understanding mouse brain cell types and circuits. However, the degree of conservation in …
understanding mouse brain cell types and circuits. However, the degree of conservation in …
PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation
Y Nagai, E Kikuchi, W Lerchner, K Inoue, B Ji… - Nature …, 2016 - nature.com
The rostromedial caudate (rmCD) of primates is thought to contribute to reward value
processing, but a causal relationship has not been established. Here we use an inhibitory …
processing, but a causal relationship has not been established. Here we use an inhibitory …
Rapid molecular profiling of defined cell types using viral TRAP
Translational profiling methodologies enable the systematic characterization of cell types in
complex tissues, such as the mammalian brain, where neuronal isolation is exceptionally …
complex tissues, such as the mammalian brain, where neuronal isolation is exceptionally …
Advances in optogenetic and chemogenetic methods to study brain circuits in non-human primates
Over the last 10 years, the use of opto-and chemogenetics to modulate neuronal activity in
research applications has increased exponentially. Both techniques involve the genetic …
research applications has increased exponentially. Both techniques involve the genetic …
Chemogenetic inactivation reveals the inhibitory control function of the prefronto-striatal pathway in the macaque brain
The lateral prefrontal cortex (LPFC) has a strong monosynaptic connection with the caudate
nucleus (CdN) of the striatum. Previous human MRI studies have suggested that this LPFC …
nucleus (CdN) of the striatum. Previous human MRI studies have suggested that this LPFC …