Abstract mRNA vaccines have evolved from being a mere curiosity to emerging as COVID-
19 vaccine front-runners. Recent advancements in the field of RNA technology, vaccinology …

The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Abstract Poly (α-l-lysine)(PLL) is a class of water-soluble, cationic biopolymer composed of α-
l-lysine structural units. The previous decade witnessed tremendous progress in the …

Nanoparticle (NP)-based mRNA cancer vaccines hold great promise to realize personalized
cancer treatments. To advance this technology requires delivery formulations for efficient …

The recent emergence of nanomedicine has revolutionized the therapeutic landscape and
necessitated the creation of more sophisticated drug delivery systems. Polymeric …

Gene-based therapies have emerged as a new modality for combating a myriad of currently
incurable diseases. However, the fragile nature of gene therapeutics has significantly …

RNA interference (RNAi) has proved to be a promising modality for disease treatment.
However, the promise of conventional RNA therapeutics for clinical application is severely …

MicroRNAs (miRNAs) are short (~ 21–23 nucleotides), non-coding endogenous RNA
molecules that modulate gene expression at the post-transcriptional level via the …

Abstract Poly-L-lysine (PLL) is a water-soluble biopolymer consist of repeating unit of L-
lysine. It displays intrinsic non-antigenicity, antibacterial property, biocompatibility, and …

Delivery of small interfering RNA (siRNA) provides one of the most powerful strategies for
downregulation of therapeutic targets. Despite the widely explored capabilities of this …