Modern approaches in the discovery and development of plant-based natural products and their analogues as potential therapeutic agents

A Najmi, SA Javed, M Al Bratty, HA Alhazmi - Molecules, 2022 - mdpi.com
Natural products represents an important source of new lead compounds in drug discovery
research. Several drugs currently used as therapeutic agents have been developed from …

Nanotechnologies in food science: applications, recent trends, and future perspectives

SH Nile, V Baskar, D Selvaraj, A Nile, J Xiao, G Kai - Nano-micro letters, 2020 - Springer
Nanotechnology is a key advanced technology enabling contribution, development, and
sustainable impact on food, medicine, and agriculture sectors. Nanomaterials have potential …

Status and challenges of plant-anticancer compounds in cancer treatment

P Garcia-Oliveira, P Otero, AG Pereira, F Chamorro… - Pharmaceuticals, 2021 - mdpi.com
Nowadays, cancer is one of the deadliest diseases in the world, which has been estimated
to cause 9.9 million deaths in 2020. Conventional treatments for cancer commonly involve …

[HTML][HTML] Podophyllotoxin and its derivatives: Potential anticancer agents of natural origin in cancer chemotherapy

S Motyka, K Jafernik, H Ekiert, J Sharifi-Rad… - Biomedicine & …, 2023 - Elsevier
The use of plant secondary metabolites has gained considerable attention among clinicians
in the prevention and treatment of cancer. A secondary metabolite isolated mainly from the …

Nitrogen-containing heterocycles as anticancer agents: An overview

DK Lang, R Kaur, R Arora, B Saini… - Anti-Cancer Agents in …, 2020 - ingentaconnect.com
Background: Cancer is spreading all over the world, and it is becoming the leading cause of
major deaths. Today's most difficult task for every researcher is to invent a new drug that can …

Podophyllotoxin: history, recent advances and future prospects

Z Shah, UF Gohar, I Jamshed, A Mushtaq, H Mukhtar… - Biomolecules, 2021 - mdpi.com
Podophyllotoxin, along with its various derivatives and congeners are widely recognized as
broad-spectrum pharmacologically active compounds. Etoposide, for instance, is the …

Pharmacological potential of fungal endophytes associated with medicinal plants: A review

BS Adeleke, OO Babalola - Journal of Fungi, 2021 - mdpi.com
Endophytic microbes are microorganisms that colonize the intracellular spaces within the
plant tissues without exerting any adverse or pathological effects. Currently, the world …

Lactones: Classification, synthesis, biological activities, and industrial applications

SK Sartori, MAN Diaz, G Diaz-Muñoz - Tetrahedron, 2021 - Elsevier
This review summarizes the current knowledge on lactones, a class of biologically active
natural products isolated from a wide range of living organisms. Butenolide, 5, 6 …

Plant associated fungal endophytes as a source of natural bioactive compounds

N Rai, P Kumari Keshri, A Verma, SC Kamble, P Mishra… - Mycology, 2021 - Taylor & Francis
Endophytes are a potent source of bioactive compounds that mimic plant-based metabolites.
The relationship of host plant and endophyte is significantly associated with alteration in …

A comprehensive review of topoisomerase inhibitors as anticancer agents in the past decade

X Liang, Q Wu, S Luan, Z Yin, C He, L Yin, Y Zou… - European journal of …, 2019 - Elsevier
The topoisomerase enzymes play an important role in DNA metabolism, and searching for
enzyme inhibitors is an important target in the search for new anticancer drugs. Discovery of …