Neonates have little immunological memory and a developing immune system, which
increases their vulnerability to infectious agents. Recent advances in the understanding of …

The human immune system comprises cellular and molecular components designed to
coordinately prevent infection while avoiding potentially harmful inflammation and …

Newborn infants are highly susceptible to infection. This defect in host defence has
generally been ascribed to the immaturity of neonatal immune cells; however, the degree of …

Heterogeneity is a hallmark feature of the adaptive immune system in vertebrates. Following
infection, naive T cells differentiate into various subsets of effector and memory T cells …

Background Autism spectrum disorder (ASD) is a complex neurodevelopmental condition
that can be reliably diagnosed at age 24 months. Immunological phenomena, including …

In spite of their precipitous encounter with the environment, newborn infants cannot readily
mount T helper type 1 (TH1) cell antibacterial and antiviral responses. Instead, they show …

Neonates, especially those born prematurely, are at high risk of morbidity and mortality from
sepsis. Multiple factors, including prematurity, invasive life-saving medical interventions, and …

Uterine life is arguably the most critical time in developmental programming, when
environmental exposures may have the greatest potential to influence evolving fetal …

Immunisation of the newborn represents a key global strategy in overcoming morbidity and
mortality due to infection in early life. Potential limitations, however, include poor …

Dengue virus (DV) infection is the most prevalent mosquito-borne viral disease and its
manifestation has been shown to be contributed in part by the host immune responses. In …