Revisiting the neurovascular unit
S Schaeffer, C Iadecola - Nature neuroscience, 2021 - nature.com
The brain is supplied by an elaborate vascular network that originates extracranially and
reaches deep into the brain. The concept of the neurovascular unit provides a useful …
reaches deep into the brain. The concept of the neurovascular unit provides a useful …
Fluid transport in the brain
MK Rasmussen, H Mestre… - Physiological …, 2022 - journals.physiology.org
The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …
wakefulness, the brain is geared fully toward processing information and behaving, while …
Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid
Macrophages are important players in the maintenance of tissue homeostasis. Perivascular
and leptomeningeal macrophages reside near the central nervous system (CNS) …
and leptomeningeal macrophages reside near the central nervous system (CNS) …
The glymphatic system: a novel component of fundamental neurobiology
LM Hablitz, M Nedergaard - Journal of Neuroscience, 2021 - Soc Neuroscience
Throughout the body, lymphatic fluid movement supports critical functions including
clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the …
clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the …
Circadian control of brain glymphatic and lymphatic fluid flow
LM Hablitz, V Plá, M Giannetto, HS Vinitsky… - Nature …, 2020 - nature.com
The glymphatic system is a network of perivascular spaces that promotes movement of
cerebrospinal fluid (CSF) into the brain and clearance of metabolic waste. This fluid …
cerebrospinal fluid (CSF) into the brain and clearance of metabolic waste. This fluid …
The glymphatic system: Current understanding and modeling
We review theoretical and numerical models of the glymphatic system, which circulates
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …
A mesothelium divides the subarachnoid space into functional compartments
K Møllgård, FRM Beinlich, P Kusk, LM Miyakoshi… - Science, 2023 - science.org
The central nervous system is lined by meninges, classically known as dura, arachnoid, and
pia mater. We show the existence of a fourth meningeal layer that compartmentalizes the …
pia mater. We show the existence of a fourth meningeal layer that compartmentalizes the …
Astrocyte endfeet in brain function and pathology: open questions
Astrocyte endfeet enwrap the entire vascular tree within the central nervous system, where
they perform important functions in regulating the blood-brain barrier (BBB), cerebral blood …
they perform important functions in regulating the blood-brain barrier (BBB), cerebral blood …
[HTML][HTML] The brain's glymphatic system: current controversies
The glymphatic concept along with the discovery of meningeal lymphatic vessels have, in
recent years, highlighted that fluid is directionally transported within the central nervous …
recent years, highlighted that fluid is directionally transported within the central nervous …
The glymphatic system: implications for drugs for central nervous system diseases
TJ Lohela, TO Lilius, M Nedergaard - Nature Reviews Drug Discovery, 2022 - nature.com
In the past decade, evidence for a fluid clearance pathway in the central nervous system
known as the glymphatic system has grown. According to the glymphatic system concept …
known as the glymphatic system has grown. According to the glymphatic system concept …