Fibrillar protein aggregation is a hallmark of a variety of human diseases. Examples include
the deposition of amyloid-β and tau in Alzheimer's disease, and that of α-synuclein in …

Parkinson's disease (PD) is the second more common neurodegenerative disease with
increasing incidence worldwide associated to the population ageing. Despite increasing …

Aberrant phase separation of globular proteins is associated with many diseases. Here, we
use a model protein system to understand how the unfolded states of globular proteins drive …

Acute intermittent porphyria (AIP) is an autosomal dominant inherited disease with low
clinical penetrance, caused by mutations in the hydroxymethylbilane synthase (HMBS) …

The lack of detailed insight into the structure of aggregates formed by the huntingtin protein
(HTT) has hampered the efforts to develop therapeutics and diagnostics targeting pathology …

Genetic variation in alpha-1 antitrypsin (AAT) causes AAT deficiency (AATD) through liver
aggregation-associated gain-of-toxic pathology and/or insufficient AAT activity in the lung …

Parkinson's disease (PD) is a common chronic neurodegenerative disease, and the heat
shock proteins (HSPs) are proved to be of great value for PD. In addition, HSPs can maintain …

The aberrant aggregation of proteins is implicated in the onset and pathogenesis of a wide
range of neurodegenerative disorders, including Alzheimer's and Parkinson's diseases …

From a physicochemical viewpoint, amyloid fibril formation is a phase transition from soluble
to crystal-like sates limited by supersaturation. It occurs only above solubility (ie, the …

An extracellular network of molecular chaperones protects a diverse array of proteins that
reside in or pass through extracellular spaces. Proteins in the extracellular milieu face …