Prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs), more than meets the eye: a critical review
AM Qandil - International journal of molecular sciences, 2012 - mdpi.com
The design and the synthesis of prodrugs for nonsteroidal anti-inflammatory drugs (NSAIDs)
have been given much attention by medicinal chemists, especially in the last decade. As a …
have been given much attention by medicinal chemists, especially in the last decade. As a …
NSAIDs: Old acquaintance in the pipeline for cancer treatment and prevention─ Structural modulation, mechanisms of action, and bright future
S Ramos-Inza, AC Ruberte, C Sanmartin… - Journal of Medicinal …, 2021 - ACS Publications
The limitations of current chemotherapeutic drugs are still a major issue in cancer treatment.
Thus, targeted multimodal therapeutic approaches need to be strategically developed to …
Thus, targeted multimodal therapeutic approaches need to be strategically developed to …
Nonsteroidal anti‐inflammatory therapy: a journey toward safety
C Pereira‐Leite, C Nunes, SK Jamal… - Medicinal research …, 2017 - Wiley Online Library
The efficacy of nonsteroidal anti‐inflammatory drugs (NSAIDs) against inflammation, pain,
and fever has been supporting their worldwide use in the treatment of painful conditions and …
and fever has been supporting their worldwide use in the treatment of painful conditions and …
[HTML][HTML] The mitochondria-targeted sulfide delivery molecule attenuates drugs-induced gastropathy. Involvement of heme oxygenase pathway.
K Magierowska, D Wójcik-Grzybek, E Korbut… - Redox Biology, 2023 - Elsevier
Hydrogen sulfide (H 2 S) signaling and H 2 S-prodrugs maintain redox balance in
gastrointestinal (GI) tract. Predominant effect of any H 2 S-donor is mitochondrial. Non …
gastrointestinal (GI) tract. Predominant effect of any H 2 S-donor is mitochondrial. Non …
Prodrugs of non-steroidal anti-inflammatory drugs (NSAIDs): a long march towards synthesis of safer NSAIDs
S Sehajpal, DN Prasad… - Mini reviews in medicinal …, 2018 - ingentaconnect.com
As a therapeutic group, non-steroidal anti-inflammatory drugs (NSAIDs) are among the most
widely used, prescribed and over the counter (OTC) medications for the treatment of …
widely used, prescribed and over the counter (OTC) medications for the treatment of …
NOSH-aspirin (NBS-1120), a novel nitric oxide-and hydrogen sulfide-releasing hybrid has enhanced chemo-preventive properties compared to aspirin, is …
R Kodela, M Chattopadhyay… - Biochemical …, 2015 - Elsevier
Aspirin is chemopreventive; however, side effects preclude its long-term use. NOSH-aspirin
(NBS-1120), a novel hybrid that releases nitric oxide and hydrogen sulfide, was designed to …
(NBS-1120), a novel hybrid that releases nitric oxide and hydrogen sulfide, was designed to …
Analysis of Post-Traumatic Brain Injury Gene Expression Signature Reveals Tubulins, Nfe2l2, Nfkb, Cd44 and S100a4 as Treatment Targets
A Lipponen, J Paananen, N Puhakka, A Pitkänen - Scientific reports, 2016 - nature.com
We aimed to define the chronically altered gene expression signature of traumatic brain
injury (TBI-sig) to discover novel treatments to reverse pathologic gene expression or …
injury (TBI-sig) to discover novel treatments to reverse pathologic gene expression or …
The dichotomous role of H2S in cancer cell biology? Deja vu all over again
K Kashfi - Biochemical pharmacology, 2018 - Elsevier
Nitric oxide (NO) a gaseous free radical is one of the ten smallest molecules found in nature,
while hydrogen sulfide (H 2 S) is a gas that bears the pungent smell of rotten eggs. Both are …
while hydrogen sulfide (H 2 S) is a gas that bears the pungent smell of rotten eggs. Both are …
[HTML][HTML] Prodrugs of NSAIDs: A review
Results: As an outcome the search for a prodrug or mutual prodrug with reduced toxicity has
continued during recent years. This present review emphasizes the common help to revamp …
continued during recent years. This present review emphasizes the common help to revamp …
Gastrointestinal safety, chemotherapeutic potential, and classic pharmacological profile of NOSH‐naproxen (AVT‐219) a dual NO‐ and H2S‐releasing hybrid
M Chattopadhyay, R Kodela… - Pharmacology …, 2016 - Wiley Online Library
Naproxen (NAP) is a potent nonsteroidal anti‐inflammatory drug (NSAID) with a favorable
cardiovascular profile. However, its long‐term use may lead to serious gastrointestinal and …
cardiovascular profile. However, its long‐term use may lead to serious gastrointestinal and …