The design and the synthesis of prodrugs for nonsteroidal anti-inflammatory drugs (NSAIDs)
have been given much attention by medicinal chemists, especially in the last decade. As a …

The limitations of current chemotherapeutic drugs are still a major issue in cancer treatment.
Thus, targeted multimodal therapeutic approaches need to be strategically developed to …

The efficacy of nonsteroidal anti‐inflammatory drugs (NSAIDs) against inflammation, pain,
and fever has been supporting their worldwide use in the treatment of painful conditions and …

Hydrogen sulfide (H 2 S) signaling and H 2 S-prodrugs maintain redox balance in
gastrointestinal (GI) tract. Predominant effect of any H 2 S-donor is mitochondrial. Non …

As a therapeutic group, non-steroidal anti-inflammatory drugs (NSAIDs) are among the most
widely used, prescribed and over the counter (OTC) medications for the treatment of …

Aspirin is chemopreventive; however, side effects preclude its long-term use. NOSH-aspirin
(NBS-1120), a novel hybrid that releases nitric oxide and hydrogen sulfide, was designed to …

We aimed to define the chronically altered gene expression signature of traumatic brain
injury (TBI-sig) to discover novel treatments to reverse pathologic gene expression or …

Nitric oxide (NO) a gaseous free radical is one of the ten smallest molecules found in nature,
while hydrogen sulfide (H 2 S) is a gas that bears the pungent smell of rotten eggs. Both are …

Results: As an outcome the search for a prodrug or mutual prodrug with reduced toxicity has
continued during recent years. This present review emphasizes the common help to revamp …

Naproxen (NAP) is a potent nonsteroidal anti‐inflammatory drug (NSAID) with a favorable
cardiovascular profile. However, its long‐term use may lead to serious gastrointestinal and …