Selection forces underlying aneuploidy patterns in cancer
TC Klockner, CS Campbell - Molecular & Cellular Oncology, 2024 - Taylor & Francis
Aneuploidy, the presence of an aberrant number of chromosomes, has been associated with
tumorigenesis for over a century. More recently, advances in karyotyping techniques have …
tumorigenesis for over a century. More recently, advances in karyotyping techniques have …
The Role of Metabolism in Shaping Enzyme Structures Over 400 Million Years of Evolution
O Lemke, BM Heineike, S Viknander, N Cohen… - bioRxiv, 2024 - biorxiv.org
The functions of cells and proteins depend on their biochemical microenvironment. In order
to understand how biochemical constraints shaped protein structural evolution, we coupled …
to understand how biochemical constraints shaped protein structural evolution, we coupled …
Premature aging in aneuploid yeast is caused in part by aneuploidy-induced defects in Ribosome Quality Control
LE Escalante, J Hose, H Howe, N Paulsen, M Place… - bioRxiv, 2024 - biorxiv.org
Premature aging is a hallmark of Down syndrome, caused by trisomy of human chromosome
21, but the reason is unclear and difficult to study in humans. We used an aneuploid model …
21, but the reason is unclear and difficult to study in humans. We used an aneuploid model …