Abstract The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal
transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell …

Immunotherapy has been a remarkable clinical advancement in the treatment of cancer. T
cells are pivotal to the efficacy of current cancer immunotherapies, including immune …

Mitochondria are organelles that are able to adjust and respond to different stressors and
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …

The field of chimeric antigen receptor (CAR) modified T cell therapy has rapidly expanded in
the past few decades. As of today, there are six CAR T cell products that have been …

Chimeric antigen receptor (CAR) T cells have not induced meaningful clinical responses in
solid tumors. Loss of T cell stemness, poor expansion capacity, and exhaustion during …

Over the last decade, the survival outcome of patients with multiple myeloma (MM) has been
substantially improved with the emergence of novel therapeutic agents, such as proteasome …

Metabolic fitness of T cells is essential for their vitality, which is largely dependent on the
behavior of the mitochondria. The nature of mitochondrial behavior in tumor-infiltrating T …

Chimeric antigen receptor (CAR) T cells have achieved true clinical success in treating
hematological malignancy patients, laying the foundation of CAR T cells as a new pillar of …

Effector, memory and exhaustion are three phenotypes of CD8+ T cell. In tumor
microenvironment (TME), metabolism dysfunction of the three should take the blame for …

Chimeric antigen receptor T (CAR-T) cell therapy has significantly improved the life
expectancy for patients with refractory or relapse B cell lymphoma. As for B cell acute …