T cell chimeric antigen receptor (CAR) technology has allowed for the introduction of a high
degree of tumor selectivity into adoptive cell transfer therapies. Evolution of this technology …

The strength of the interaction between T‐cell receptors (TCRs) and their ligands,
peptide/major histocompatibility complex complexes (pMHCs), is one of the most frequently …

Background Adoptive T-cell therapy relying on conventional T cells transduced with T-cell
receptors (TCRs) or chimeric antigen receptors (CARs) has caused substantial tumor …

Natural killer T (NKT) cells represent a cell subpopulation that combines characteristics of
natural killer (NK) cells and T cells. Through their endogenous T-cell receptors (TCRs), they …

Chimeric antigen receptor (CAR)‐T cells have been used successfully for cancer
immunotherapy. While substantial tumor regression was observed in leukaemia and …

Background: In therapeutic cancer vaccination, monocyte-derived dendritic cells (moDCs)
efficiently activate specific T-cell responses; however, optimizing the activation of innate …

Tumor cells can develop immune escape mechanisms to bypass T cell recognition, eg,
antigen loss or downregulation of the antigen presenting machinery, which represents a …

Electroporation (EP) of mRNA into human cells is a broadly applicable method to transiently
express proteins of choice in a variety of different cell types. We have spent more than a …

Natural killer (NK) cells, members of the innate immune system, play an important role in the
rejection of HLA class I negative tumor cells. Hence, a therapeutic vaccine, which can …

The adoptive transfer of engineered T cells represents an important approach in
immunotherapy of melanoma. However, relapse of the tumor can occur due to immune …