[HTML][HTML] Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology

K Gouveia-Freitas, AJ Bastos-Leite - Neuroradiology, 2021 - Springer
Perivascular spaces (PVS) of the brain, often called Virchow-Robin spaces, comprise fluid,
cells and connective tissue, and are externally limited by astrocytic endfeet. PVS are …

Current concepts in intracranial interstitial fluid transport and the glymphatic system: part II—imaging techniques and clinical applications

JM Klostranec, D Vucevic, KD Bhatia, HGJ Kortman… - Radiology, 2021 - pubs.rsna.org
The glymphatic system is a recently discovered network unique to the central nervous
system that allows for dynamic exchange of interstitial fluid (ISF) and cerebrospinal fluid …

[HTML][HTML] Reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) for evaluating interstitial fluid diffusivity and glymphatic function …

T Taoka, R Ito, R Nakamichi, K Kamagata… - Japanese journal of …, 2022 - Springer
Purpose The diffusion tensor image analysis along the perivascular space (DTI-ALPS)
method was developed to evaluate the brain's glymphatic function or interstitial fluid …

Sleep, cerebrospinal fluid, and the glymphatic system: a systematic review

PLH Chong, D Garic, MD Shen, I Lundgaard… - Sleep medicine …, 2022 - Elsevier
Current theories of the glymphatic system (GS) hypothesize that it relies on cerebrospinal
fluid (CSF) circulation to disseminate growth factors and remove metabolic waste from the …

Assessment of the DTI‐ALPS parameter along the perivascular space in older adults at risk of dementia

CE Steward, VK Venkatraman, E Lui… - Journal of …, 2021 - Wiley Online Library
ABSTRACT BACKGROUND AND PURPOSE Recently, there has been growing interest in
the glymphatic system (the functional waste clearance pathway for the central nervous …

Association of MRI indices of glymphatic system with amyloid deposition and cognition in mild cognitive impairment and Alzheimer disease

K Kamagata, C Andica, K Takabayashi, Y Saito… - Neurology, 2022 - AAN Enterprises
Background and Objectives The glymphatic system is a whole-brain perivascular network,
which promotes CSF/interstitial fluid exchange. Alterations to this system may play a pivotal …

[HTML][HTML] Neuroimaging findings related to glymphatic system alterations in older adults with metabolic syndrome

C Andica, K Kamagata, K Takabayashi, J Kikuta… - Neurobiology of …, 2023 - Elsevier
Objective The glymphatic system is a glial-based perivascular network that promotes brain
metabolic waste clearance. Reduced glymphatic flow has been observed in rat models of …

Neuroimaging uncovers distinct relationships of glymphatic dysfunction and motor symptoms in Parkinson's disease

Y Qin, R He, J Chen, X Zhou, X Zhou, Z Liu, Q Xu… - Journal of …, 2023 - Springer
Background Studies of glymphatic dysfunction in Parkinson's disease (PD) patients have
attracted much attention in recent years. However, the relationships between glymphatic …

Noninvasive characterization of human glymphatics and meningeal lymphatics in an in vivo model of blood–brain barrier leakage

CH Wu, JF Lirng, YH Ling, YF Wang, HM Wu… - Annals of …, 2021 - Wiley Online Library
Objective To evaluate human glymphatics and meningeal lymphatics noninvasively.
Methods This prospective study implemented 3‐dimensional (3D) isotropic contrast …

Glymphatic system dysfunction in patients with juvenile myoclonic epilepsy

HJ Lee, DA Lee, KJ Shin, KM Park - Journal of Neurology, 2022 - Springer
Objective The glymphatic system is a glial cell-dependent waste clearance pathway in the
brain that is essential for the maintenance of brain homeostasis. In this study, we evaluated …