Recent introduction of new analgesics into the clinic is best described as a slow process
with activity classified into two main areas: improving analgesic efficacy/potency and …

Ocular discomfort and eye pain are frequently reported by patients with dry eye disease
(DED), and their management remains a real therapeutic challenge for the Ophthalmologist …

Previous studies proved the effectiveness of an intravenous PEGylated liposomal
formulation of opiorphin (1 mg/mL) in protecting the drug from enzymatic degradation, and …

Acute or chronic pain is a major source of impairment in quality of life and affects a
substantial part of the population. To date, pain is alleviated by a limited range of treatments …

Background The objective of this study was to compare the changes in the
electroencephalogram (EEG) in response to noxious stimuli with tail flick and hot plate …

Objectives Opiorphin is a recently discovered peptide shown to inhibit the enkephalin-
degrading enzymes and prolong the effects of enkephalins. Although opiorphin is found in …

The scarcity and limited risk/benefit ratio of painkillers available on the market, in addition to
the opioid crisis, warrant reflection on new innovation strategies. The pharmacopoeia of …

Objectives Opiorphin is a pentapeptide isolated from human saliva that suppresses pain
from chemically induced inflammation and acute physical pain. Burning mouth syndrome …

Abstract Objectives Idiopathic Burning mouth syndrome (iBMS) is a poorly understood
affection characterized by persistent pain in the oral cavity without any clinical or biological …

Purpose: Opiorphin is an endogenous inhibitor of enkephalin-degrading enzymes. It has a
strong analgesic effect in chemical and mechanical pain models. We aimed to evaluate the …