Rituximab is a chimeric mouse/human monoclonal antibody (mAb) therapy with binding
specificity to CD20. It was the first therapeutic antibody approved for oncology patients and …

Size exclusion chromatography (SEC) is a historical technique widely employed for the
detailed characterization of therapeutic proteins and can be considered as a reference and …

Ion-exchange chromatography (IEX) is a historical technique widely used for the detailed
characterization of therapeutic proteins and can be considered as a reference and powerful …

Antibody drug conjugates (ADCs) are macromolecules composed of cytotoxic drugs
covalently attached via a conditionally stable linker to monoclonal antibodies (mAbs). ADCs …

The rapid growth of approved biotherapeutics, eg, monoclonal antibodies or
immunoglobulins G (IgGs), demands improved techniques for their quality control …

Protein biopharmaceuticals such as monoclonal antibodies and therapeutic proteins are
currently in widespread use for the treatment of various life-threatening diseases including …

Hydrophobic interaction chromatography (HIC) is a historical strategy used for the analytical
purification and characterization of proteins. Similarly to what can be done in reversed …

Ion exchange chromatography (IEX) is a historical technique widely used for the detailed
characterization of therapeutic proteins and can be considered as a reference and powerful …

Remsima®(infliximab) was recently approved as the world's first biosimilar monoclonal
antibody (mAb) in both the European Union and Korea. To achieve this, extensive …

Hydrogen/deuterium exchange mass spectrometry (HDX-MS) has within the last 25 years
evolved to become a well-established technique for analysing the solution-phase …