Heart failure with reduced ejection fraction (HFrEF) develops when cardiac output falls as a
result of cardiac injury. The most well-recognized of the compensatory homeostatic …

The origin of Metazoa remained—until recently—the most enigmatic of all phylogenetic
problems. Sponges [Porifera] as 'living fossils', positioned at the base of multicellular …

Aging is associated with an increase in myocardial extracellular matrix components and
contractile dysfunction. Transforming growth factor-β1 (TGF-β1) has been shown to regulate …

Cardiac hypertrophy can lead to heart failure (HF), but it is unpredictable which
hypertrophied myocardium will progress to HF. We surmised that apart from hypertrophy …

Objective: Determine the effect of a matrix metalloproteinase inhibitor (MMPi) and
angiotensin converting enzyme inhibitor (ACEi) on collagen, MMP, tissue inhibitors of MMPs …

Discordant findings are reported on the left ventricular transforming growth factor-β1 (TGF-
β1) mRNA levels in various rat models. Left ventricular TGF-β1 mRNA levels did not differ …

N-Acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a natural inhibitor of pluripotent
hematopoietic stem cell entry into the S phase of the cell cycle and is normally present in …

Although several risk factors including hypertension, cardiac hypertrophy, coronary artery
disease, and diabetes are known to result in heart failure, elderly subjects are more …

Marine demosponges (phylum Porifera) are rich sources for potent bioactive compounds.
With the establishment of the primmorph system from sponges, especially from Suberites …

Background—Although increased activity of angiotensin-converting enzyme (ACE) has
been associated with increased cardiac collagen, no studies to date have established a …