The management of bacterial infections is becoming a major clinical challenge due to the
rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome …

Defensins are a family of cationic antimicrobial peptides active against a broad range of
infectious microbes including bacteria, viruses and fungi, playing important roles as innate …

Pathway analysis is a key analytical stage in the interpretation of omics data, providing a
powerful method for detecting alterations in cellular processes. We recently developed a …

As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth
cells, neutrophils, and epithelial cells, contributing to host defense. Their biological functions …

Host-defense peptides (HDPs) are vital components of innate immunity in all vertebrates.
While their antibacterial activity toward bacterial cells was the original focus for research …

BACKGROUND Reproductive tract infection is an important factor leading to male and
female infertility. Among female infertility factors, microbial and viral infections are the main …

The percutaneous device dilemma describes etiological factors, centered around the
disrupted epithelial tissue surrounding non-remodelable devices, that contribute to rampant …

There is a growing interest in the complex role of host defense peptides (HDPs) in the
pathophysiology of several immune-mediated inflammatory diseases. The physicochemical …

Antimicrobial peptides (AMPs) are produced by several organisms as their first line of
defense. Constituted by amino acids, they may present different mechanisms of action. The …

The glycocalyx surrounds every eukaryotic cell and is a complex mesh of proteins and
carbohydrates. It consists of proteoglycans with glycosaminoglycan side chains, which are …