Targeting the PI3K/AKT/mTOR signaling pathway in lung cancer: an update regarding potential drugs and natural products

Iksen, S Pothongsrisit, V Pongrakhananon - Molecules, 2021 - mdpi.com
Lung cancer is one of the most common cancers and has a high mortality rate. Due to its
high incidence, the clinical management of the disease remains a major challenge. Several …

Autophagy-related microRNAs: possible regulatory roles and therapeutic potential in and gastrointestinal cancers

MH Pourhanifeh, M Vosough… - Pharmacological …, 2020 - Elsevier
Gastrointestinal (GI) cancers with a high incidence rate and adverse complications are
associated with severe morbidity and mortality around the world. It is well recognized that …

Anti-Biofilm and Antibacterial Activities of Cycas media R. Br Secondary Metabolites: In Silico, In Vitro, and In Vivo Approaches

NGM Attallah, OM Al-Fakhrany, E Elekhnawy… - Antibiotics, 2022 - mdpi.com
Enterococcus species possess many virulence factors that have an essential role in
exacerbating the infections caused by them. The current study aimed to evaluate the effect of …

A Network Pharmacology Approach to Investigate the Anticancer Mechanism and Potential Active Ingredients of Rheum palmatum L. Against Lung Cancer via …

Q Zhang, J Liu, R Li, R Zhao, M Zhang, S Wei… - Frontiers in …, 2020 - frontiersin.org
Rheum palmatum L.(RPL) is a known traditional herbal medicine with the functions of “heat-
clearing and damp-drying” in traditional Chinese medicine. Its anti-cancer effect against lung …

Natural biflavonoids as potential therapeutic agents against microbial diseases

JC Menezes, VR Campos - Science of The Total Environment, 2021 - Elsevier
Microbes broadly constitute several organisms like viruses, protozoa, bacteria, and fungi
present in our biosphere. Fast-paced environmental changes have influenced contact of …

PI3K/Akt/mTOR pathways inhibitors with potential prospects in non-small-cell lung cancer

KS Alharbi, MAJ Shaikh, WH Almalki… - Journal of …, 2022 - dl.begellhouse.com
Lung cancer is the leading cause of cancer-related mortality across the globe. The most
prevalent pathological form of lung cancer is non-small-cell lung cancer (NSCLC). Elevated …

Investigation of the mechanism of Isobavachalcone in treating rheumatoid arthritis through a combination strategy of network pharmacology and experimental …

S Wang, Q Du, J Sun, S Geng, Y Zhang - Journal of Ethnopharmacology, 2022 - Elsevier
Ethnopharmacology relevance Isobavachalcone (IBC) is a natural chalcone compound
widely distributed in traditional Chinese medicine Psoralea corylifolia L., and Tibetan …

An integrated strategy for effective-component discovery of astragali radix in the treatment of lung cancer

B Yang, N Yang, Y Chen, M Zhu, Y Lian… - Frontiers in …, 2021 - frontiersin.org
Lung cancer is one of the most devastating diseases worldwide, with high incidence and
mortality worldwide, and the anticancer potential of traditional Chinese medicine (TCM) has …

[HTML][HTML] Fisetin inhibits inflammation and induces autophagy by mediating PI3K/AKT/mTOR signaling in LPS-induced RAW264. 7 cells

Y Sun, H Qin, H Zhang, X Feng, L Yang… - Food & Nutrition …, 2021 - ncbi.nlm.nih.gov
Background Fisetin, a natural potent flavonoid, has various beneficial, pharmacological
activities. In this study, we investigated expression changes of the fisetin regulating genes in …

FGFC1 Selectively Inhibits Erlotinib-Resistant Non-Small Cell Lung Cancer via Elevation of ROS Mediated by the EGFR/PI3K/Akt/mTOR Pathway

S Yan, B Zhang, J Feng, H Wu, N Duan… - Frontiers in …, 2022 - frontiersin.org
Non-small cell lung cancer (NSCLC) is one of the most common malignancies in the world.
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have been used as …