Chronic kidney disease–associated pruritus (CKD-aP) is a common, troubling and in some
cases debilitating problem for patients with CKD and end-stage renal disease. Despite a …

Chronic kidney disease-associated pruritus (CKD-aP) is a distressing, often overlooked
condition in patients with CKD and end-stage renal disease. It affects~ 40% of patients with …

The κ-opioid receptor (KOR) has emerged as an attractive drug target for pain management
without addiction, and biased signaling through particular pathways of KOR may be key to …

Atopic dermatitis (AD) is among the most frequent inflammatory skin diseases in humans,
affecting up to 20% of children and 10% of adults in higher income countries. Chronic …

Background Uraemic pruritus is a common symptom in patients with chronic kidney disease
undergoing haemodialysis (HD) treatment. Etiopathogenesis of uraemic pruritus is complex …

All preclinical procedures for analgesic drug discovery involve two components: 1) a “pain
stimulus”(the principal independent variable), which is delivered to an experimental subject …

Importance Patients with pruritus receiving hemodialysis frequently experience oppressive
physical and psychiatric symptoms that directly affect their quality of life and increase …

Psoriasis and atopic dermatitis (AD) are two common chronic inflammatory skin diseases.
Although showing different etiology and clinical manifestations, patients with either disease …

Pruritus or itch generated in the skin is one of the most widespread symptoms associated
with various dermatological and systemic (immunological) conditions. Although many details …

Chronic pruritus remains a central societal issue because of its high occurrence and the
substantial decrease in quality of life it may cause to affected individuals. Not only …