Neonicotinoid insecticides: molecular targets, resistance, and toxicity
K Matsuda, M Ihara, DB Sattelle - Annual review of …, 2020 - annualreviews.org
Neonicotinoids have been used to protect crops and animals from insect pests since the
1990s, but there are concerns regarding their adverse effects on nontarget organisms …
1990s, but there are concerns regarding their adverse effects on nontarget organisms …
[HTML][HTML] Structure, function, and modulation of GABAA receptors
E Sigel, ME Steinmann - Journal of Biological Chemistry, 2012 - ASBMB
The GABA A receptors are the major inhibitory neurotransmitter receptors in mammalian
brain. Each isoform consists of five homologous or identical subunits surrounding a central …
brain. Each isoform consists of five homologous or identical subunits surrounding a central …
Crystal structure of a human GABAA receptor
PS Miller, AR Aricescu - Nature, 2014 - nature.com
Type-A γ-aminobutyric acid receptors (GABAARs) are the principal mediators of rapid
inhibitory synaptic transmission in the human brain. A decline in GABAAR signalling triggers …
inhibitory synaptic transmission in the human brain. A decline in GABAAR signalling triggers …
The benzodiazepine binding sites of GABAA receptors
Everyday activity is based on a subtle equilibrium of excitatory and inhibitory neuronal
systems. The most prominent players in neuronal inhibition are synaptic and extrasynaptic …
systems. The most prominent players in neuronal inhibition are synaptic and extrasynaptic …
GABAkines–Advances in the discovery, development, and commercialization of positive allosteric modulators of GABAA receptors
Positive allosteric modulators of γ-aminobutyric acid-A (GABA A) receptors or GABAkines
have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other …
have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other …
Principles of activation and permeation in an anion-selective Cys-loop receptor
Fast inhibitory neurotransmission is essential for nervous system function and is mediated
by binding of inhibitory neurotransmitters to receptors of the Cys-loop family embedded in …
by binding of inhibitory neurotransmitters to receptors of the Cys-loop family embedded in …
Time-resolved cryo-EM using a combination of droplet microfluidics with on-demand jetting
S Torino, M Dhurandhar, A Stroobants, R Claessens… - Nature …, 2023 - nature.com
Single-particle cryogenic electron microscopy (cryo-EM) allows reconstruction of high-
resolution structures of proteins in different conformations. Protein function often involves …
resolution structures of proteins in different conformations. Protein function often involves …
Towards a comprehensive understanding of anesthetic mechanisms of action: a decade of discovery
Significant progress has been made in the 21st century towards a comprehensive
understanding of the mechanisms of action of general anesthetics, coincident with progress …
understanding of the mechanisms of action of general anesthetics, coincident with progress …
Diversity of native nicotinic receptor subtypes in mammalian brain
Neuronal nicotinic acetylcholine receptors (nAChRs) are a heterogeneous family of
pentameric ligand-gated cation channels that are expressed throughout the brain and …
pentameric ligand-gated cation channels that are expressed throughout the brain and …
Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites
Abstract γ-Aminobutyric acid receptors (GABAARs) are vital for controlling excitability in the
brain. This is emphasized by the numerous neuropsychiatric disorders that result from …
brain. This is emphasized by the numerous neuropsychiatric disorders that result from …