Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan
(CSPG)-containing structures that surround the soma and dendrites of various mammalian …

Perineuronal nets (PNNs) are specialized extracellular matrix structures that surround
specific neurons in the brain and spinal cord, appear during critical periods of development …

Perineuronal nets (PNNs) surround specific neurons in the brain and are involved in various
forms of plasticity and clinical conditions. However, our understanding of the PNN role in …

Epilepsy can be both a primary pathology and a secondary effect of many neurological
conditions. Many papers show that neuroinflammation is a product of epilepsy, and that in …

Research on critical periods of brain development is greatly expanding our understanding of
the cellular and molecular mechanisms underlying the epochs of heightened plasticity …

Perineuronal nets (PNNs) are specialized structures of the extracellular matrix that surround
the soma and proximal dendrites of certain neurons in the central nervous system …

The medial prefrontal cortex (mPFC) is a major contributor to relapse to cocaine in humans
and to reinstatement in rodent models of cocaine use disorder. Output from the mPFC is …

While persistence of fear memories is essential for survival, a failure to inhibit fear in
response to harmless stimuli is a feature of anxiety disorders. Extinction training only …

Grid cells are part of a widespread network which supports navigation and spatial memory.
Stable grid patterns appear late in development, in concert with extracellular matrix …

Perineuronal net (PNN) accumulation around parvalbumin-expressing (PV) inhibitory
interneurons marks the closure of critical periods of high plasticity, whereas PNN removal …