Results Valsartan/hydrochlorothiazide treatment significantly increased mean (±SD) soluble
Klotho (from 432.7±179 to 506.4±226.8 pg/ml; P= 0.01) and reduced serum phosphate (from …

Aging is associated with progressive functional deterioration and structural changes in the
kidney. Changes in the activity or responsiveness of the renin-angiotensin system (RAS) …

Klotho is a type-1 membrane protein predominantly produced in the kidney, the extracellular
domain of which is secreted into the systemic circulation. Membranous and secreted Klotho …

Hydrogen sulfide (H 2 S) is one of the biologically active gases (gasotransmitters), which
plays an important role in various physiological processes and aging. Its production in the …

Angiotensin-converting enzyme inhibitors (ACEi) for renin-angiotensin-aldosterone system
(RAAS) blockade are routinely used to slow CKD progression. However, vitamin D may also …

Chronic Kidney Disease (CKD), a disorder that affects 11% of the world's population, is
characterized by an acceleration in skeletal, immune, renal, and cardiovascular aging that …

Klotho is an anti-aging protein mainly expressed in the kidney. Reduced Klotho expression
closely correlates with the development and progression of chronic kidney disease (CKD) …

Background: The neuroinflammatory process is associated with the pathogenesis of many
cardiovascular disorders, particularly with hypertension. In this regard, the deficiency of …

Introduction It has been reported that klotho deficiency is associated with oxidative stress
and inflammation in experimental kidney disease models. Patients with end-stage renal …

Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone mainly produced by bone
that acts in the kidney through FGF receptors and Klotho. Here we investigated whether the …