P-glycoprotein, the founding member of the ATP-binding cassette (ABC) family of drug
transporters, was first identified almost three decades ago and shown to confer resistance to …

Biosensors are devices that combine a biochemical recognition/binding element (ligand)
with a signal conversion unit (transducer). Biosensors are already used for several clinical …

MEG3 is a human homolog of the mouse maternal imprinted gene, Gtl2. Gtl2 has been
suggested to be involved in fetal and postnatal development and to function as an RNA …

The methylation of CpG islands is associated with transcriptional repression and, in cancer,
leads to the abnormal silencing of tumor suppressor genes. Because aberrant …

Ovarian cancer is the most lethal of all gynecologic neoplasms. Early-stage malignancy is
frequently asymptomatic and difficult to detect and thus, by the time of diagnosis, most …

DNA methylation is an epigenetic phenomenon known to play an increasingly important role
in the etiology of cancer. Changes in DNA methylation patterns particularly in the promoter …

Despite the clonal origin of most tumors, their tremendous heterogeneity suggests that
cancer progression springs from the combined forces of both genetic and epigenetic events …

The N‐terminal tails of the histones are subject to many enzyme‐mediated post‐
translational modifications, such as lysine acetylation, lysine and arginine methylation …

Purpose: Urokinase (uPA) is expressed in a number of highly invasive malignancies
including breast cancer. Because production of uPA is associated with breast cancer …

Aberrant CpG island methylation contributes to the pathogenesis of various malignancies.
However, little is known about the association of epigenetic abnormalities with multistep …