Simple Summary The tumor microenvironment plays an important role in determining the
biological behavior of several of the more aggressive malignancies. Among the various cell …

Most tumors exhibit intra-tumor heterogeneity, which is associated with disease progression
and an impaired response to therapy. Cancer cell plasticity has been proposed as being an …

Breast cancer starts as a local disease, but it can metastasize to the lymph nodes and distant
organs. At primary diagnosis, prognostic markers are used to assess whether the transition …

The need for innovative anticancer treatments with high effectiveness and low toxicity is
urgent due to the development of malignancies that are resistant to chemotherapeutic …

Imaging of collectively invading cocultures of carcinoma cells and stromal fibroblasts reveals
that the leading cell is always a fibroblast and that carcinoma cells move within tracks in the …

A role for fibroblasts in physiological and pathological angiogenesis is now well recognized;
however, the precise mechanisms underlying their action have not been determined. Using …

Morphogenesis is the remarkable process by which cells self-assemble into complex tissues
and organs that exhibit specialized form and function during embryological development …

Cutaneous tissue repair aims at restoring the barrier function of the skin. To achieve this,
defects need to be replaced by granulation tissue to form new connective tissue, and …

Our understanding of the tumor microenvironment (TME), including the interplay between
tumor cells, stromal cells, immune cells, and extracellular matrix components, is mandatory …

Cancer cells display enhanced growth rates and a resistance to apoptosis. The ability of
cancer cells to evade homeostasis and proliferate uncontrollably while avoiding …