Activin/nodal signaling and NANOG orchestrate human embryonic stem cell fate decisions by controlling the H3K4me3 chromatin mark
A Bertero, P Madrigal, A Galli, NC Hubner… - Genes & …, 2015 - genesdev.cshlp.org
Stem cells can self-renew and differentiate into multiple cell types. These characteristics are
maintained by the combination of specific signaling pathways and transcription factors that …
maintained by the combination of specific signaling pathways and transcription factors that …
TGF-β family signaling in embryonic and somatic stem-cell renewal and differentiation
AC Mullen, JL Wrana - Cold Spring Harbor perspectives …, 2017 - cshperspectives.cshlp.org
Soon after the discovery of transforming growth factor-β (TGF-β), seminal work in vertebrate
and invertebrate models revealed the TGF-β family to be central regulators of tissue …
and invertebrate models revealed the TGF-β family to be central regulators of tissue …
The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation
The histone H3 Lys 27 (H3K27) demethylase JMJD3 has been shown to play important
roles in transcriptional regulation and cell differentiation. However, the mechanism …
roles in transcriptional regulation and cell differentiation. However, the mechanism …
[HTML][HTML] Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors
P Martin-Malpartida, M Batet, Z Kaczmarska… - Nature …, 2017 - nature.com
Smad transcription factors activated by TGF-β or by BMP receptors form trimeric complexes
with Smad4 to target specific genes for cell fate regulation. The CAGAC motif has been …
with Smad4 to target specific genes for cell fate regulation. The CAGAC motif has been …
[HTML][HTML] Coordinated genomic control of ciliogenesis and cell movement by RFX2
The mechanisms linking systems-level programs of gene expression to discrete cell
biological processes in vivo remain poorly understood. In this study, we have defined such a …
biological processes in vivo remain poorly understood. In this study, we have defined such a …
[HTML][HTML] Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling
Long non-coding RNAs (lncRNAs) are known players in the regulatory circuitry of the self-
renewal in human embryonic stem cells (hESCs). However, most hESC-specific lncRNAs …
renewal in human embryonic stem cells (hESCs). However, most hESC-specific lncRNAs …
Large-scale quality analysis of published ChIP-seq data
ChIP-seq has become the primary method for identifying in vivo protein–DNA interactions on
a genome-wide scale, with nearly 800 publications involving the technique appearing in …
a genome-wide scale, with nearly 800 publications involving the technique appearing in …
[HTML][HTML] Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway
Definitive endoderm differentiation is crucial for generating respiratory and gastrointestinal
organs including pancreas and liver. However, whether epigenetic regulation contributes to …
organs including pancreas and liver. However, whether epigenetic regulation contributes to …
Activin and BMP4 synergistically promote formation of definitive endoderm in human embryonic stem cells
Human embryonic stem cells (hESCs) herald tremendous promise for the production of
clinically useful cell types for the treatment of injury and disease. Numerous reports …
clinically useful cell types for the treatment of injury and disease. Numerous reports …
[HTML][HTML] SMADs and YAP compete to control elongation of β-catenin: LEF-1-recruited RNAPII during hESC differentiation
The Wnt3a/β-catenin and Activin/SMAD2, 3 signaling pathways synergize to induce
endodermal differentiation of human embryonic stem cells; however, the underlying …
endodermal differentiation of human embryonic stem cells; however, the underlying …