Human pluripotent stem cells (hPSCs), including human embryonic stem cells and induced
pluripotent stem cells, are defined by their abilities to self-renew and to differentiate into any …

Cell differentiation is directed by extracellular cues and intrinsic epigenetic modifications,
which control chromatin organization and transcriptional activation. Central to this process is …

Retinal progenitors are initially found in the anterior neural plate region known as the eye
field, whereas neighboring areas undertake telencephalic or hypothalamic development …

The TGFβ superfamily regulates a broad range of cellular processes, including proliferation,
cell-fate specification, differentiation, and migration. Molecular mechanisms underlying this …

In vitro differentiation of mouse embryonic stem cells (ESCs) into retinal fates can be used to
study the roles of exogenous factors acting through multiple signaling pathways during …

Epigenetic modifications to histones may promote either activation or repression of the
transcription of nearby genes. Recent experimental studies show that the promoters of many …

Background Because the liver is central to the physiology of the body, primary hepatocytes
are widely used in liver pathology and physiological research, such as liver drug screening …

The differentiation of human pluripotent stem cells toward the hepatocyte lineage can
potentially provide an unlimited source of functional hepatocytes for transplantation and …

ΔEGFR is a potent glioblastoma oncogene which has been studied primarily as a plasma
membrane kinase. Using intracranial xenograft studies in mice, we show that blocking …

How TGF-β signaling switches from enforcing pluripotency to promoting mesendodermal
differentiation remains an open question. Recently in Cell Reports, Beyer et al …