Background: Tacrolimus (Tac, or FK506), a calcineurin inhibitor (CNI), is the first-line
immunosuppressant which consists of the footstone as immunosuppressive regimens in …

Drug lag, recently discussed extensively in Japan, can be divided into two phases: clinical
development time and application review time. The former factor is still an important problem …

ABSTRACT Introduction: Tacrolimus (Tac) is effective in preventing acute rejection but has
considerable toxicity and inter-individual variability in pharmacokinetics and …

Background The ATP-binding cassette sub-family B member 1 (ABCB1) gene, which
encodes the p-glycoprotein at the blood–brain barrier, is investigated for patients' …

目的建立一种快速, 准确的检测免疫抑制剂常见代谢相关基因多态性的微阵列芯片技术,
明确肝移植供, 受体细胞色素P450 家族细胞色素3A5 (cytochromeP4503A5, CYP3A5) …

Breviscapine (BRE) is usually used for long-term use in patients with cardiovascular
diseases such as coronary heart disease, angina pectoris, and cerebral thrombosis. It is …

P-Glycoprotein (P-gp, encoded by MDR1 gene) plays an important role in determining
bioavailability and pharmacologic effects of many drugs. There is increasing evidence that P …

Interindividual and interethnic variability of drug responses could be attributed to the
differences of genetic polymorphisms in the drug metabolizing enzymes and transporters …

Tacrolimus is one of the most important immunosuppressant drugs used in organ
transplants. The primary enzymes responsible for the metabolism of tacrolimus are …

Detection of CYP3A5 variant alleles, and knowledge about their allelic frequency in Uyghur
ethnic groups, is important to establish the clinical relevance of screening for these …