The molecular pathophysiology of depression and the new therapeutics

H Tian, Z Hu, J Xu, C Wang - MedComm, 2022 - Wiley Online Library
Major depressive disorder (MDD) is a highly prevalent and disabling disorder. Despite the
many hypotheses proposed to understand the molecular pathophysiology of depression, it is …

[HTML][HTML] A microbial-based approach to mental health: the potential of probiotics in the treatment of depression

D Johnson, V Letchumanan, CC Thum… - Nutrients, 2023 - mdpi.com
Probiotics are currently the subject of intensive research pursuits and also represent a multi-
billion-dollar global industry given their vast potential to improve human health. In addition …

Role of inflammatory mechanisms in major depressive disorder: from etiology to potential pharmacological targets

BR Kouba, L de Araujo Borba, P Borges de Souza… - Cells, 2024 - mdpi.com
The involvement of central and peripheral inflammation in the pathogenesis and prognosis
of major depressive disorder (MDD) has been demonstrated. The increase of pro …

[HTML][HTML] Depression pathophysiology: Astrocyte mitochondrial melatonergic pathway as crucial hub

G Anderson - International Journal of Molecular Sciences, 2022 - mdpi.com
Major depressive disorder (MDD) is widely accepted as having a heterogenous
pathophysiology involving a complex mixture of systemic and CNS processes. A …

[HTML][HTML] The current state of research for psychobiotics use in the management of psychiatric disorders–A systematic literature review

O Vasiliu - Frontiers in Psychiatry, 2023 - frontiersin.org
The need to find new therapeutic interventions in patients diagnosed with psychiatric
disorders is supported by the data suggesting high rates of relapse, chronic evolution …

The role of dietary intake of live microbes in the association between leisure-time physical activity and depressive symptoms: A population-based study

Y You, R Wang, J Li, F Cao, Y Zhang… - Applied Physiology …, 2024 - cdnsciencepub.com
Current research has shown promising associations between factors such as diet, total
physical activity, and mental health outcomes, acknowledging the intricate interplay between …

Potential of postbiotics for the treatment of metabolic disorders

N Mishra, A Garg, S Ashique, S Bhatt - Drug Discovery Today, 2024 - Elsevier
Postbiotics, the next generation of probiotics, are extracts that are free of living and
nonviable bacteria and show strong modulatory effects on the gut flora. Examples include …

Effect of Dendrobium officinale polysaccharides on central nervous system disease: Based on gut microbiota

L Xu, X Zeng, Y Liu, Z Wu, X Zheng, X Zhang - International Journal of …, 2023 - Elsevier
Dendrobium officinale has anti-inflammatory effects and is one of the well-known functional
foods. Dendrobium officinale polysaccharide (DOP) can reduce intestinal barrier disruption …

[HTML][HTML] Biology of cyclooxygenase-2: An application in depression therapeutics

Y He, Y Han, X Liao, M Zou, Y Wang - Frontiers in Psychiatry, 2022 - frontiersin.org
Depressive Disorder is a common mood disorder or affective disorder that is dominated by
depressed mood. It is characterized by a high incidence and recurrence. The onset of …

Targeting the gut–microbiota–brain axis in irritable bowel disease to improve cognitive function–recent knowledge and emerging therapeutic opportunities

H Tang, X Chen, S Huang, G Yin, X Wang… - Reviews in the …, 2023 - degruyter.com
The brain–gut axis forms a bidirectional communication system between the gastrointestinal
(GI) tract and cognitive brain areas. Disturbances to this system in disease states such as …