The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation
and trafficking of inflammatory mediators as well as tumor progression and metastasis. The …

Epithelial-mesenchymal transition (EMT) is a critical process in the development of many
tissues and organs in multicellular organisms that its important role in the pathogenesis of …

Tumor-associated macrophages (TAMs) have been implicated in the promotion of breast
cancer growth and metastasis, and multiple TAM-secreted cytokines have been identified …

The components of the tumor microenvironment (TME) in solid tumors, especially
chemokines, are currently attracting much attention from scientists. C‐X‐C motif chemokine …

Myeloid-derived suppressor cells (MDSCs) expand in tumor-bearing host. They suppress
anti-tumor immune response and promote tumor growth. Chemokines play a vital role in …

In recent years, the role of neutrophils in cancer biology has been a matter of increasing
interest. Many patients with advanced cancer show high levels of neutrophilia, tumor …

Bone is one of the most common sites for metastasis across cancers. Cancer cells that travel
through the vasculature and invade new tissues can remain in a non-proliferative dormant …

Simple Summary Tumor-associated macrophages (TAMs) play major roles in solid tumor
development. They can have both anti-tumor and pro-tumor properties depending on their …

Lung tumor-infiltrating neutrophils are known to support growth and dissemination of cancer
cells and to suppress T cell responses. However, the precise impact of tissue neutrophils on …

Chemokines are a class of pro-inflammatory cytokines that can recruit and activate
chemotactic cells. C‐X‐C motif chemokine ligand 5 (CXCL5) is a member of the chemokine …