[HTML][HTML] Protein-based nanoparticles as drug delivery systems

S Hong, DW Choi, HN Kim, CG Park, W Lee, HH Park - Pharmaceutics, 2020 - mdpi.com
Nanoparticles have been extensively used as carriers for the delivery of chemicals and
biomolecular drugs, such as anticancer drugs and therapeutic proteins. Natural …

Metabolomics in diabetes and diabetic complications: insights from epidemiological studies

Q Jin, RCW Ma - Cells, 2021 - mdpi.com
The increasing prevalence of diabetes and its complications, such as cardiovascular and
kidney disease, remains a huge burden globally. Identification of biomarkers for the …

Antioxidant properties of anthocyanins and their mechanism of action in atherosclerosis

C Garcia, CN Blesso - Free Radical Biology and Medicine, 2021 - Elsevier
Atherosclerosis develops due to lipid accumulation in the arterial wall and sclerosis as result
of increased hyperlipidemia, oxidative stress, lipid oxidation, and protein oxidation …

[HTML][HTML] COVID‐19—Associated dyslipidemia: Implications for mechanism of impaired resolution and novel therapeutic approaches

AV Sorokin, SK Karathanasis, ZH Yang… - The FASEB …, 2020 - ncbi.nlm.nih.gov
The current coronavirus disease 2019 (COVID‐19) pandemic presents a global challenge
for managing acutely ill patients and complications from viral infection. Systemic …

Mendelian randomization in cardiometabolic disease: challenges in evaluating causality

MV Holmes, M Ala-Korpela, GD Smith - Nature Reviews Cardiology, 2017 - nature.com
Mendelian randomization (MR) is a burgeoning field that involves the use of genetic variants
to assess causal relationships between exposures and outcomes. MR studies can be …

Nanodiscs: a versatile nanocarrier platform for cancer diagnosis and treatment

J Bariwal, H Ma, GA Altenberg, H Liang - Chemical Society Reviews, 2022 - pubs.rsc.org
Cancer therapy is a significant challenge due to insufficient drug delivery to the cancer cells
and non-selective killing of healthy cells by most chemotherapy agents. Nano-formulations …

Effects of low-carbohydrate diets v. low-fat diets on body weight and cardiovascular risk factors: a meta-analysis of randomised controlled trials

N Mansoor, KJ Vinknes, MB Veierød… - British Journal of …, 2016 - cambridge.org
The effects of low-carbohydrate (LC) diets on body weight and cardiovascular risk are
unclear, and previous studies have found varying results. Our aim was to conduct a meta …

RIPK1 Expression Associates With Inflammation in Early Atherosclerosis in Humans and Can Be Therapeutically Silenced to Reduce NF-κB Activation and …

D Karunakaran, MA Nguyen, M Geoffrion, D Vreeken… - Circulation, 2021 - Am Heart Assoc
Background: Chronic activation of the innate immune system drives inflammation and
contributes directly to atherosclerosis. We previously showed that macrophages in the …

Elimination of established tumors with nanodisc-based combination chemoimmunotherapy

R Kuai, W Yuan, S Son, J Nam, Y Xu, Y Fan… - Science …, 2018 - science.org
Although immune checkpoint blockade has shown initial success for various cancers, only a
small subset of patients benefits from this therapy. Some chemotherapeutic drugs have been …

HDL cholesterol: reappraisal of its clinical relevance

W März, ME Kleber, H Scharnagl, T Speer… - Clinical Research in …, 2017 - Springer
Background While several lines of evidence prove that elevated concentrations of low-
density lipoproteins (LDL) causally contribute to the development of atherosclerosis and its …