We carried out a genome-wide association study of type-2 diabetes (T2D) in individuals of
South Asian ancestry. Our discovery set included 5,561 individuals with T2D (cases) and …

Aims/hypothesis Although a family history of type 2 diabetes is a strong risk factor for the
disease, the factors mediating this excess risk are poorly understood. In the InterAct case …

Both human and animal studies indicate that environmental exposures experienced during
early life can robustly influence risk for adult disease. Moreover, environmental exposures …

Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the
insulin-producing β cells in the endocrine pancreas to overcome insulin resistance in …

The rapid rise of obesity during the past decades has coincided with a profound shift of our
living environment, including unhealthy dietary patterns, a sedentary lifestyle, and physical …

The genetic basis of most traits is highly polygenic and dominated by non-coding alleles. It is
widely assumed that such alleles exert small regulatory effects on the expression of cis …

Patients with established type 2 diabetes display both β-cell dysfunction and insulin
resistance. To define fundamental processes leading to the diabetic state, we examined the …

Low cardiorespiratory fitness is a powerful predictor of morbidity and cardiovascular
mortality. In 473 sedentary adults, all whites, from 99 families of the Health, Risk Factors …

We report a new method to estimate the predictive performance of polygenic models for risk
prediction and assess predictive performance for ten complex traits or common diseases …

In addition to genetic predisposition, environmental and lifestyle factors contribute to the
pathogenesis of type 2 diabetes (T2D). Epigenetic changes may provide the link for …