Interleukin-1 and the inflammasome as therapeutic targets in cardiovascular disease

A Abbate, S Toldo, C Marchetti, J Kron… - Circulation …, 2020 - Am Heart Assoc
The intracellular sensing protein termed NLRP3 (for NACHT, LRR, and PYD domains-
containing protein 3) forms a macromolecular structure called the NLRP3 inflammasome …

A synopsis of the evidence for the science and clinical management of cardiovascular-kidney-metabolic (CKM) syndrome: a scientific statement from the American …

CE Ndumele, IJ Neeland, KR Tuttle, SL Chow… - Circulation, 2023 - Am Heart Assoc
A growing appreciation of the pathophysiological interrelatedness of metabolic risk factors
such as obesity and diabetes, chronic kidney disease, and cardiovascular disease has led …

Heart disease and stroke statistics—2019 update: a report from the American Heart Association

EJ Benjamin, P Muntner, A Alonso, MS Bittencourt… - Circulation, 2019 - Am Heart Assoc
Summary Each year, the American Heart Association (AHA), in conjunction with the National
Institutes of Health and other government agencies, brings together in a single document the …

Sex differences in arterial hypertension: a scientific statement from the ESC Council on Hypertension, the European Association of Preventive Cardiology, Association …

E Gerdts, I Sudano, S Brouwers, C Borghi… - European Heart …, 2022 - academic.oup.com
There is strong evidence that sex chromosomes and sex hormones influence blood
pressure (BP) regulation, distribution of cardiovascular (CV) risk factors and co-morbidities …

Cardiovascular risks associated with gender and aging

JL Rodgers, J Jones, SI Bolleddu… - Journal of …, 2019 - mdpi.com
The aging and elderly population are particularly susceptible to cardiovascular disease. Age
is an independent risk factor for cardiovascular disease (CVD) in adults, but these risks are …

Bioactive Compounds and Biological Functions of Garlic (Allium sativum L.)

A Shang, SY Cao, XY Xu, RY Gan, GY Tang, H Corke… - Foods, 2019 - mdpi.com
Garlic (Allium sativum L.) is a widely consumed spice in the world. Garlic contains diverse
bioactive compounds, such as allicin, alliin, diallyl sulfide, diallyl disulfide, diallyl trisulfide …

Undulating changes in human plasma proteome profiles across the lifespan

B Lehallier, D Gate, N Schaum, T Nanasi, SE Lee… - Nature medicine, 2019 - nature.com
Aging is a predominant risk factor for several chronic diseases that limit healthspan.
Mechanisms of aging are thus increasingly recognized as potential therapeutic targets …

Historical redlining and cardiovascular health: the multi-ethnic study of atherosclerosis

MS Mujahid, X Gao, LP Tabb… - Proceedings of the …, 2021 - National Acad Sciences
We investigated historical redlining, a government-sanctioned discriminatory policy, in
relation to cardiovascular health (CVH) and whether associations were modified by present …

Minimally invasive delivery of therapeutic agents by hydrogel injection into the pericardial cavity for cardiac repair

D Zhu, Z Li, K Huang, TG Caranasos, JS Rossi… - Nature …, 2021 - nature.com
Cardiac patches are an effective way to deliver therapeutics to the heart. However, such
procedures are normally invasive and difficult to perform. Here, we develop and test a …

Prevalence and predictors of death and severe disease in patients hospitalized due to COVID-19: A comprehensive systematic review and meta-analysis of 77 studies …

K Dorjee, H Kim, E Bonomo, R Dolma - PloS one, 2020 - journals.plos.org
Introduction Progression of COVID-19 to severe disease and death is insufficiently
understood. Objective Summarize the prevalence of risk factors and adverse outcomes and …