Pain is a common clinical condition. However, the mechanisms underlying pain are not yet
fully understood. It is known that the neuroimmune system plays a critical role in the …

Stimulator of interferon genes (STING) is an innate immune signaling protein critical to
infections, autoimmunity, and cancer. STING signaling is also emerging as an exciting and …

Background Neuropathic pain is a common and severely disabling state that affects millions
of people worldwide. Microglial activation in the spinal cord plays a critical role in the …

Background Our previous study indicated that reactive oxygen species (ROS) are critically
involved in chronic pain. Sestrin2 (Sesn2), a novel stress-inducible protein, is evidenced to …

Neuroinflammation plays a vital role in the development of neuropathic pain and is mediated
mainly by microglia. Suppressing microglial M1-polarization attenuates neuropathic pain …

Clinical and preclinical interest in Type 2 diabetes (T2D)-associated cognitive dysfunction
(TDACD) has grown in recent years. However, the precise mechanisms underlying TDACD …

Background Neuroinflammation in the peripheral nervous system has been linked to cancer
metastasis-induced bone pain. The stimulator of interferon genes (STING), an innate …

Microglia, resident immune cells in the central nervous system, play a role in
neuroinflammation and the development of neuropathic pain. We found that the stimulator of …

Paclitaxel-induced neuropathic pain (PINP) is a progressive and refractory side effect of
chemotherapy with few effective treatments at present. It is well-established that astrocytes …

Chronic pain is a notable health concern because of its prevalence, persistence, and
associated mental stress. Drugs targeting chronic pain with potent abirritation, and minimal …