One of the adverse outcomes of acute inflammatory response is progressing to the chronic
stage or transforming into an aggressive process, which can develop rapidly and result in …

Esculetin is a coumarin compound, which belongs to the class of benzopyrone enriched in
various plants such as Sonchus grandifolius, Aesculus turbinata, etc. Free radicals lead to …

Inflammation plays an important role in the development of rheumatoid arthritis (RA). NR4A1
is an anti-inflammatory orphan nuclear receptor involved in protection from inflammatory …

Simple Summary Since its first description 35 years ago, the transcription factor NF-κB
(nuclear factor κ-light-chain-enhancer of activated B cells) has been shown to be a key …

Rheumatoid arthritis (RA) is a destructive inflammatory autoimmune disease that causes
pain and disability. Many of the currently available drugs for treating RA patients are aimed …

Backgrounds Rheumatoid arthritis (RA) is a chronic and systemic autoimmune disease
characterized by synovial inflammation-mediated progressive destruction of the cartilage …

Abstract Interleukin-1 receptor-associated kinase 4 (IRAK4) is a pivotal enzyme in the Toll-
like receptor (TLR)/MYD88 dependent signaling pathway, which is highly activated in …

Ammodaucus leucotrichus exhibits promising pharmacological activity, hinting at anti-
inflammatory and anti-arthritic effects. This study investigated seed extracts from …

Abstract Objectives Schisandrin B (Sch B) has been shown to possess anti-inflammatory
and antioxidant properties, however, its antirheumatoid arthritis properties and potential …

Dramatically increased glycolysis has been found in inflamed joints in rheumatoid arthritis
(RA) due to the increased demand for energy and biosynthetic precursors to support the …