PARP inhibitor resistance: a tug-of-war in BRCA-mutated cells
SM Noordermeer, H van Attikum - Trends in cell biology, 2019 - cell.com
Poly-(ADP)-ribose polymerase (PARP) inhibition is synthetic lethal with deficiency for
homologous recombination (HR), a pathway essential for DNA double-strand break repair …
homologous recombination (HR), a pathway essential for DNA double-strand break repair …
Sources of DNA double-strand breaks and models of recombinational DNA repair
A Mehta, JE Haber - Cold Spring Harbor perspectives in …, 2014 - cshperspectives.cshlp.org
DNA is subject to many endogenous and exogenous insults that impair DNA replication and
proper chromosome segregation. DNA double-strand breaks (DSBs) are one of the most …
proper chromosome segregation. DNA double-strand breaks (DSBs) are one of the most …
Targeted genome modifications in soybean with CRISPR/Cas9
Background The ability to selectively alter genomic DNA sequences in vivo is a powerful tool
for basic and applied research. The CRISPR/Cas9 system precisely mutates DNA …
for basic and applied research. The CRISPR/Cas9 system precisely mutates DNA …
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
Y Shiloh, Y Ziv - Nature reviews Molecular cell biology, 2013 - nature.com
The protein kinase ataxia-telangiectasia mutated (ATM) is best known for its role as an
apical activator of the DNA damage response in the face of DNA double-strand breaks …
apical activator of the DNA damage response in the face of DNA double-strand breaks …
[HTML][HTML] Biological consequences of radiation-induced DNA damage: relevance to radiotherapy
ME Lomax, LK Folkes, P O'neill - Clinical oncology, 2013 - Elsevier
DNA damage of exposed tumour tissue leading to cell death is one of the detrimental effects
of ionising radiation that is exploited, with beneficial consequences, for radiotherapy. The …
of ionising radiation that is exploited, with beneficial consequences, for radiotherapy. The …
Repair of DNA double-strand breaks by mammalian alternative end-joining pathways
A Sallmyr, AE Tomkinson - Journal of Biological Chemistry, 2018 - ASBMB
Alternative end-joining (a-EJ) pathways, which repair DNA double-strand breaks (DSBs),
are initiated by end resection that generates 3′ single strands. This reaction is shared, at …
are initiated by end resection that generates 3′ single strands. This reaction is shared, at …
DNA damage foci: Meaning and significance
K Rothkamm, S Barnard, J Moquet… - Environmental and …, 2015 - Wiley Online Library
The discovery of DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and
the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a …
the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a …
[HTML][HTML] DNA damage and repair in plants–from models to crops
V Manova, D Gruszka - Frontiers in plant science, 2015 - frontiersin.org
The genomic integrity of every organism is constantly challenged by endogenous and
exogenous DNA-damaging factors. Mutagenic agents cause reduced stability of plant …
exogenous DNA-damaging factors. Mutagenic agents cause reduced stability of plant …
Integration of Agrobacterium T-DNA into the Plant Genome
SB Gelvin - Annual review of genetics, 2017 - annualreviews.org
Agrobacterium strains transfer a single-strand form of T-DNA (T-strands) and Virulence (Vir)
effector proteins to plant cells. Following transfer, T-strands likely form complexes with Vir …
effector proteins to plant cells. Following transfer, T-strands likely form complexes with Vir …
DNA-PK: a dynamic enzyme in a versatile DSB repair pathway
DNA double stranded breaks (DSBs) are the most cytoxic DNA lesion as the inability to
properly repair them can lead to genomic instability and tumorigenesis. The prominent DSB …
properly repair them can lead to genomic instability and tumorigenesis. The prominent DSB …